Page 113 - 《中国药科大学学报》2026年第2期

第 57 卷第 2 期 范潇敏，等：艾考糊精腹膜透析液中的 α-双羰基类降解产物邻苯二胺衍生化 HPLC-MS/MS 测定研究 239

全反应需 10 h（图 6），且在 3~10 h 内峰面积变化率 toneal fluid and polyglucose transport[J]. Front Physiol, 2019,
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且该类化合物含呋喃基团，能够使用紫外检测器 promote α-dicarbonyl formation in glucose-containing peri-
直接测定，无需复杂的衍生化前处理，因此未在本次 toneal dialysis fluids[J]. Glycoconj J, 2021, 38(3): 319-329.
衍生化定量方法中对该两种物质进行方法学验证和 [5] Gensberger-Reigl S, Huppert J, Pischetsrieder M. Quantifica-
tion of reactive carbonyl compounds in icodextrin-based peri-
测定。
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200 de novo formation of nine major glucose degradation products
Peak area/×10 4 150 [7] 4268.
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100
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50 quantitative profiling of fructose degradation products revealed
the formation of thirteen reactive carbonyl compounds and
0 higher reactivity compared to glucose[J]. J Agric Food Chem,
0 1 2 3 4 5 6 7 8 9 10 11 12 13 2024, 72(34): 19131-19142.
t/h
[8] Leitzen S, Vogel M, Steffens M, et al. Quantification of degra-
Figure 6 Reaction time profile of monocarbonyl degradation dation products formed during heat sterilization of glucose solu-
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在艾考糊精腹膜透析液中鉴定得到 4 种 α-双羰基
6-15.
类降解产物（3-DG、3-DGal、4-DG、3,4-DGE）与两 [10] Martens RJH, Broers NJH, Canaud B, et al. Advanced glyca-
种单羰基类降解产物（糠醛、5-羟甲基糠醛），并对 tion endproducts and dicarbonyls in end-stage renal disease: as-
4 种 α-双羰基类降解产物及其结构类似物葡萄糖醛 sociations with uraemia and courses following renal replace-
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酮进行定量分析。该定量方法专属性强、线性良
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