Page 59 - 《中国药科大学学报》2026年第1期

第 57 卷第 1 期 龙 悦，等：基于多成分定量联合化学计量学的不同产地通关藤质量评价 53

TOPSIS 法分析结果一致显示，云南和贵州产地的 32.
[11] Jin LX, Pang WW, Zhang CZ. Research progress on the anti-
通关藤整体质量较好。
colorectal cancer activity and mechanism of Marsdenia tenacis-
本研究同时检测 18 批通关藤中绿原酸、隐绿 sima[J]. J Zunyi Med Univ (遵义医科大学学报), 2023, 46(12):
原酸、芥子酸、通关藤苷 A、通关藤苷 G、通关藤 1217-1224.
[12] Dong YL, Lou C, Chen XY, et al. Exploring the mechanism of
苷 I、通关藤苷 H、苦绳苷元 A、白桦脂酸、羽扇豆
Marsdenia tenacissima in the treatment of hepatocellular carci-
醇、醇溶性浸出物和总灰分含量，实现对通关藤药 noma based on network pharmacology[J]. J Pharm Pract
材中多种活性成分的定量分析，更加全面地控制和 Serv(药学实践与服务), 2023, 41(10): 600-609.
[13] Hu YJ, Wei LY, Zhao J, et al. Mechanism of Marsdenia
评价药材质量，建立的多指标定量控制模式简单、 tenacissima against ovarian cancer based on network pharma-
易推广，可用于通关藤的内在质量控制；采用 PCA、 cology and experimental verification[J]. China J Chin Mater
FA、OPLS-DA 及加权 TOPSIS 法分析评价了 18 批 Med (中国中药杂志), 2023, 48(8): 2222-2232.
[14] Jiu X, Zhang HW, Liu H, et al. Application of chemometrics in
通关藤中绿原酸、隐绿原酸、芥子酸、通关藤苷 A、 quality markers of traditional Chinese medicine[J]. Chin Tradit
通关藤苷 G、通关藤苷 I、通关藤苷 H、苦绳苷元 Pat Med (中成药), 2021, 43(12): 3416-3421.
A、白桦脂酸、羽扇豆醇、醇溶性浸出物和总灰分含 [15] Xu QL. Design and implementation of comprehensive evalua-
tion system based on TOPSIS[J]. J Inf Manage(信息与管理研
量数据，评价方法科学客观，为通关藤道地性研究 究), 2020, 5(2/3): 70-81.
指明了方向。 [16] Yu SS, Chen MC, Li ZX, et al. Progress on chemical and phar-
macological studies of Marsdenia tenacissima[J]. Chin J Exp
Tradit Med Formulae (中国实验方剂学杂志), 2011, 17(21):
279-283.
References
[17] Villota H, Santa-González GA, Uribe D, et al. Modulatory ef-
[1] Li SY, Zhang DY, Han L, et al. Simultaneous determination of
fect of chlorogenic acid and coffee extracts on Wnt/β-catenin
three saponins in Marsdenia tenacissima from 22 producing ar- pathway in colorectal cancer cells[J]. Nutrients, 2022, 14(22):
eas by HPLC-DAD-ELSD method[J]. Chin Tradit Pat Med(中
4880.
成药), 2019, 41(5): 1144-1146.
[18] Xue D, Liu XW, Wang N, et al. Improvement effects of sinapic
[2] Zhu ZK, Guo YY, Wang P, et al. Establishment of HPLC fin-
acid on Aβ 42 -induced injury of PC12 cells and the
gerprint of Yi drugs of Marsdenia tenacissima and evaluation of
mechanism[J]. China Pharm (中国药房), 2022, 33(5): 597-
chemometrics[J]. Int J Trad Chin Med(国际中医中药杂志),
601,616.
2023, 45(12): 1549-1554.
[19] Shen TZ, Pan YL, Jiang SD, et al. Betulinic acid attenuates anx-
[3] Jia YP, Wu ZW, Li XB, et al. Chemical constituents from
iety-like behavior and oxidative stress in mice[J]. Chronic Path-
Marsdenia tenacissima and their cytotoxic activities[J]. Chin
ematol J(慢性病学杂志), 2022, 23(3): 377-380,384.
Tradit Pat Med (中成药), 2023, 45(9): 2910-2916.
[20] Wang Q, He C, Hu C, et al. Lupinol ameliorating lung injury in
[4] Zhao GQ, Chen J, He XX. Optimization of semi-bionic enzyme
Klebsiella-infected rats by inhibiting NF-κB activation[J]. Acta
extraction for steroidal saponins from Marsdenia tenacissima by
Chin Med (中医学报), 2022, 37(10): 2177-2183.
orthogonal design[J]. China Pharm (中国药师), 2022, 25(5):
[21] Chinese Pharmacopoeia Commission. Chinese Pharmacopoeia:
884-888.
part 4(中华人民共和国药典: 四部)[S]. Beijing: China Medi-
[5] Liu JW, Zhai FG, Liang QC, et al. Optimization of extraction
cal Science Press, 2020: 232-234.
process of polysaccharides from Marsdenia tenacissima by re-
[22] You GJ, Liu YN, Ren XL, et al. Research on pattern recogni-
sponse surface methodology[J]. Cereals Oils (粮食与油脂),
2022, 35(6): 116-119. tion of Paeonia lactiflora/sulfur-fumigated Paeonia lactiflora
based on PCA-Class model[J]. China J Tradit Chin Med Pharm
[6] Bai S, Li YN, Xu X, et al. Research progress on chemical con-
(中华中医药杂志), 2020, 35(5): 2315-2320.
stituents and pharmacological activities of Marsdenia tenacissi-
[23] Yan QQ, Wang JC, Zhang WY. Evaluation of quality of Valeri-
ma[J]. Pharm J Chin PLA(解放军药学学报), 2015, 31(3): 260-
264. ana officinalis from different origins based on multi indicator
[7] Chinese Pharmacopoeia Commission. Chinese Pharmacopoeia : component quantitative combined chemometrics, weighted
part 1(中华人民共和国药典: 一部)[S]. Beijing: China Medi- TOPSIS, and grey relational degree fusion model[J]. Drug Eval
cal Science Press, 2020: 309. Res (药物评价研究), 2024, 47(6): 1305-1315.
[8] Liu L, Peng YQ, Yang CX, et al. Progress on anti-tumor phar- [24] Feng XC, Zhang J, Xu YZ, et al. Quality evaluation of Clema-
macological effects and mechanism of Xiaoaiping[J]. Drug Eval tidis radix et rhizoma medicinal materials based on HPLC-
Res (药物评价研究), 2025, 48(2): 526-538. QAMS multi-components quantification combined with OPLS-
[9] Li SF, Huang JY, Han X, et al. Research progress in anti-tumor DA and weighted TOPSIS method[J]. Front Pharm Sci(药学前
components and mechanism of Marsdenia tenacissima[J]. Drug 沿), 2024, 28(12): 593-604.
Eval Res (药物评价研究), 2023, 46(1): 187-197. [25] Zhang LQ, Ma SY, Feng K, et al. Evaluation of Tripterosper-
[10] Zhao J, Meng ZY, Zhu QF, et al. Exploration on the mecha- mum chinense from different origins by HPLC multi index com-
nism of Marsdenia tenacissima against breast cancer based on ponent combined with chemometrics and weighted TOPSIS
network pharmacology and experimental verification[J]. Chin J model[J]. Drugs Clin (现代药物与临床), 2024, 39(5): 1176-
Inf Tradit Chin Med (中国中医药信息杂志), 2024, 31(9): 24- 1183.