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学报
               172                 Journal of China Pharmaceutical University 2026, 57(2): 172 − 180


                                中药皮肤药代动力学评价技术研究进展



                                             陈仪巧 ，孙 露 ，闻晓东                  1,2**
                                                     1,2
                                                                 1*
                   1
                                                                      2
                  （ 中国药科大学附属江宁中医院（南京市江宁中医院）, 南京 211100； 中国药科大学中药学院生药学系, 南京                          211198）
               摘 要 评估中药外用制剂在皮肤组织中的吸收程度一直是中药皮肤药代动力学研究的难点。近年来，为更准确表征其药
               代动力学特征，多种技术方法不断涌现，包括扩散池、皮肤微生理系统、基质辅助激光解吸/电离质谱成像、胶带剥离、微透析/
               开放式微灌流、共聚焦拉曼显微镜技术等。本文系统综述了这些方法在中药皮肤药代动力学评价中的应用进展，总结其技术
               特点与适用场景，并展望未来发展趋势，旨在为深入揭示中药活性成分在皮肤内的动态变化规律、空间分布特征及外用制剂
               配伍合理性提供新的研究思路。
               关键词 中药皮肤药代动力学；胶带剥离；微透析/开放式微灌流；共聚焦拉曼显微镜；基质辅助激光解吸/电离质谱成像
               中图分类号  R285;R969       文献标志码 A        文章编号 1000−5048(2026)02−0172−09
                                                     doi：10.11665/j.issn.1000−5048.2025090901

                引用本文 陈仪巧，孙露，闻晓东. 中药皮肤药代动力学评价技术研究进展               [J]. 中国药科大学学报，2026，57（2）：172-180.

                Cite  this  article  as:  CHEN  Yiqiao,  SUN  Lu,  WEN  Xiaodong.  Advances  in  evaluation  techniques  for  traditional  Chinese  medicine
                dermatopharmacokinetics[J]. J China Pharm Univ, 2026, 57(2): 172-180.


               Advances  in  evaluation  techniques  for  traditional  Chinese  medicine
               dermatopharmacokinetics

                           1,2
                                    1*
               CHEN Yiqiao , SUN Lu , WEN Xiaodong  1,2**
               1
                Affiliated  Jiangning  Hospital  of  Traditional  Chinese  Medicine  of  China  Pharmaceutical  University  (Jiangning  Hospital  of
                                                               2
               Traditional  Chinese  Medicine,  Nanjing  City),  Nanjing  211100;  Department  of  Pharmacognosy,  School  of  Traditional  Chinese
               Pharmacy, China Pharmaceutical University, Nanjing 211198, China
               Abstract    Evaluating the absorption of traditional Chinese medicine (TCM) formulations in skin has long been a
               challenge in cutaneous pharmacokinetic studies of TCM. In recent years, various new techniques, including diffusion
               cell,  microphysiological  system,  matrix-assisted  laser  desorption/ionization  mass  spectrometry  imaging,  tape
               stripping,  microdialysis/open-flow  microperfusion,  and  confocal  Raman  microscopy  technology,  have  been
               developed  to  characterize  and  predict  the  pharmacokinetic  profiles  of  these  formulations  more  accurately.  This
               review  systematically  summarizes  the  application  progress  of  these  methods  in  the  evaluation  of  cutaneous
               pharmacokinetics  of  TCM,  highlights  their  technical  features  and  suitable  scenarios,  and  discusses  future
               development  trends,  providing  new  research  perspectives  for  further  understanding  the  dynamic  changes,  spatial
               distribution characteristics of active ingredients in the skin, and the rationality of compatibility in topical preparations.
               Key words    traditional Chinese medicine dermatopharmacokinetics; tape stripping; microdialysis/open flow
                           microperfusion; confocal Raman microscopy; matrix-assisted laser desorption/ionization mass
                           spectrometry imaging

               This  study  was  supported  by  the  National  Key  Research  and  Development  Program  of  China(2018YFC1704503);the  Scientific
               Research Project of Jiangning Hospital Affiliated to China Pharmaceutical University(YJZD2025008)


                                              *
                    收稿日期 2025-09-09  通信作者     E-mail：398538171@qq.com
                                             **
                                                E-mail：xiaodongwen@cpu.edu.cn
                    基金项目    国家重点研发计划项目（2018YFC1704503）；中国药科大学附属江宁中医院科研项目（YJZD2025008）
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