Page 136 - 《中国药科大学学报》2026年第2期

262 学报 Journal of China Pharmaceutical University 2026, 57(2): 256 − 265 第 57 卷
A B

100 1.5
#
80 ## 1.0

SOD /(U/mg protein) 60 MDA /(nmol/mg protein) **
40

20 0.5

0 0
Control HFD AZT (50 mg/kg) Control HFD AZT (50 mg/kg)
AZT (25 mg/kg)
AZT (25 mg/kg)

Figure 5 AZT ameliorates hepatic oxidative stress in HFD-fed rats( x ± s, n = 6)
A: Hepatic superoxide dismutase (SOD) activity; B: Hepatic malondialdehyde (MDA) content
# ##
P < 0.05, P < 0.01 vs control group; **P < 0.01 vs HFD group
A B

AZT AZT PPARα
Control HFD (25 mg/kg) (50 mg/kg)
1.5
Relative protein expression (Fold change)
CPT1α 88 kD
PPARγ 58 kD 1.0

PPARα 52 kD 0.5

GAPDH 36 kD
0
Control AZT (25 mg/kg)
AZT (50 mg/kg)
HFD

C D
CPT1α PPARγ
1.5 2.5
Relative protein expression (Fold change) 1.0 Relative protein expression (Fold change) 1.5
2.0

1.0
0.5

0 0.5 0
HFD
AZT (50 mg/kg)
AZT (50 mg/kg)
HFD
Control AZT (25 mg/kg) Control AZT (25 mg/kg)
Figure 6 Zidovudine regulates the peroxisome proliferator-activated receptor (PPAR) signaling pathway in the liver of HFD-fed
rats( x ± s, n = 5)
A: Representative Western blot bands of PPARα, carnitine palmitoyltransferase 1α (CPT1α), and PPARγ in liver tissues; B: Quantitative analysis of
PPARα protein expression; C: Quantitative analysis of CPT1α protein expression; D: Quantitative analysis of PPARγ protein expression
CPT1α 的表达水平均下降，而主导脂质合成与储存 下降。
的 PPARγ 表达上调。经 AZT 干预后，PPARα 及 尽管上述变化未达到统计学显著性，但其协同
CPT1α 的表达呈上升趋势，PPARγ 的表达则相对 变化趋势与本研究观察到的表型结果一致：包括脂