Page 39 - 《中国药科大学学报》2026年第1期
P. 39

第  57 卷第  1 期                赵 磊,等:疟原虫组蛋白去乙酰化酶抑制剂研究进展                                       33

                    768.                                             modial  inhibitor  targeting  Plasmodium  falciparum  histone
               [12]   Andrews KT, Tran TN, Lucke AJ, et al. Potent antimalarial ac-  deacetylase 1[J]. Cell Discov, 2020, 6(1): 93.
                    tivity of histone deacetylase inhibitor analogues[J]. Antimicrob  [18]   Meinke PT, Colletti SL, Doss G, et al. Synthesis of apicidin-de-
                    Agents Chemother, 2008, 52(4): 1454-1461.        rived quinolone derivatives: parasite-selective histone deacety-
               [13]   Dow GS, Chen YF, Andrews KT, et al. Antimalarial activity of  lase  inhibitors  and  antiproliferative  agents[J].  J  Med  Chem,
                    phenylthiazolyl-bearing  hydroxamate-based histone   deacety-  2000, 43(25): 4919-4922.
                    lase inhibitors[J]. Antimicrob Agents Chemother, 2008, 52(10):  [19]   Collins  JE,  Lee  JW,  Bohmer  MJ,  et  al.  Cyclic  tetrapeptide
                    3467-3477.                                       HDAC inhibitors with improved Plasmodium falciparum selec-
               [14]   Engel JA, Jones AJ, Avery VM, et al. Profiling the anti-proto-  tivity and killing profile[J]. ACS Infect Dis, 2021, 7(10): 2889-
                    zoal activity of anti-cancer HDAC inhibitors against Plasmodi-  2903.
                    um and Trypanosoma parasites[J]. Int J Parasitol Drugs Drug  [20]   Ontoria JM, Paonessa G, Ponzi S, et al. Discovery of a selec-
                    Resist, 2015, 5(3): 117-126.                     tive series of inhibitors of Plasmodium falciparum HDACs[J].
               [15]   Giannini G, Battistuzzi G, Vignola D. Hydroxamic acid based  ACS Med Chem Lett, 2016, 7(5): 454-459.
                    histone  deacetylase  inhibitors  with  confirmed  activity  against  [21]   Koumpoura  CL,  Robert  A,  Athanassopoulos  CM,  et  al.  Anti-
                    the  malaria  parasite[J].  Bioorg  Med  Chem  Lett,  2015,  25(3):  malarial  inhibitors  targeting  epigenetics  or  mitochondria  in
                    459-461.                                         Plasmodium falciparum: recent survey upon synthesis and bio-
               [16]   Stenzel  K,  Chua  MJ,  Duffy  S,  et  al.  Design  and  synthesis  of  logical  evaluation  of  potential  drugs  against  malaria[J].
                    terephthalic acid-based histone deacetylase inhibitors with dual-  Molecules, 2021, 26(18): 5711.
                    stage  anti-Plasmodium  activity[J].  ChemMedChem,  2017,  [22]   Potluri V, Shandil RK, Gavara R, et al. Discovery of FNDR-
                    12(19): 1627-1636.                               20123, a histone deacetylase inhibitor for the treatment of Plas-
               [17]   Huang ZH, Li RX, Tang TK, et al. A novel multistage antiplas-  modium falciparum malaria[J]. Malar J, 2020, 19(1): 365.
   34   35   36   37   38   39   40   41   42   43   44