Page 113 - 《中国药科大学学报》2026年第1期

第 57 卷第 1 期 钱程昱，等：黄芪桂枝五物汤通过 Nrf2/HO-1 通路改善脑缺血损伤的机制研究 107

[18] Zhang Q, Jia M, Wang YF, et al. Cell death mechanisms in [25] Li HX, Zhang YM, Chen G, et al. Mechanism of total gluco-
cerebral ischemia-reperfusion injury[J]. Neurochem Res, 2022, sides of paeony inhibiting hippocampal neuron injury in rats
47(12): 3525-3542. with focal cerebral ischemia[J]. Zhejiang Med J (浙江医学),
[19] Maida CD, Norrito RL, Daidone M, et al. Neuroinflammatory 2019, 41(18): 1938-1942,1912.
mechanisms in ischemic stroke: focus on cardioembolic stroke, [26] Wang XL, Zhang W, Zhang XX, et al. Effect of ginger volatile
background, and therapeutic approaches[J]. Int J Mol Sci, 2020, oil on lysosomal-mitochondrial apoptosis in rats with cerebral
21(18): 6454. ischemia-reperfusion[J]. Tradit Chin Drug Res Clin Pharmacol
[20] Yuan Y, Qiao Y, Ding ZH, et al. Study on the regulation of
(中药新药与临床药理), 2020, 31(10): 1153-1157.
-/-
apoptosis in experimental Nrf2 intracerebral hemorrhage mice
[27] Tian P, Zhang DW, Ma K, et al. Effect of ginger total phenol on
by activating blood and removing stasis and supplementing
focal cerebral ischemic model in rats[J]. Pharmacol Clin Chin
essence and marrow[J]. Lishizhen Med Mater Med Res (时珍国
Mater Med (中药药理与临床), 2017, 33(5): 70-73.
医国药), 2022, 33(10): 2313-2317.
[28] Tan W, Fu XY, Yang RY, et al. Effects of astragaloside IV on
[21] Lyu BH, Xiong CZ, Zhang Y, et al. Baicalin alleviates cortical
oxidative damage of vascular endothelial cells by regulating
neuronal cell injury in rats with cerebral ischemia-reperfusion
Nrf2/HO-1 signaling pathway[J]. J Hunan Univ Chin Med (湖
through modulating inflammatory factors[J]. J Public Health
南中医药大学学报), 2024, 44(9): 1592-1600.
Prev Med(公共卫生与预防医学), 2022, 33(6): 28-32.
[29] Deng G, Zhou K, Fu JH. Effects of astragaloside IV against hy-
[22] Liu J. Mechanisms and active substances researches of Cin-
drogen peroxide-induced apoptosis of PC12 cells via the
namomi ramulus against rheumatoid arthritis(桂枝抗类风湿关
PI3K/Akt signaling pathway[J]. Zhejiang J Integr Tradit Chin
节炎作用机制及其物质基础研究)[D]. Chengdu: Chengdu
West Med (浙江中西医结合杂志), 2024, 34(7): 604-610.
University of Traditional Chinese Medicine, 2021.
[30] Zhang HM. Cinnamaldehyde plays a neuroprotective role by in-
[23] Pyo JH, Jeong YK, Yeo S, et al. Neuroprotective effect of trans-
hibiting neuroinflammation, oxidative stress and apoptosis after
cinnamaldehyde on the 6-hydroxydopamine-induced dopamin-
ergic injury[J]. Biol Pharm Bull, 2013, 36(12): 1928-1935. spinal cord injury[D]. Jinan: Shandong University of Tradition-
[24] Li XJ, Niu YQ, Lü SQ. Protective effect of total glucosides of al Chinese Medicine(山东中医药大学), 2024.
paeony on neuronal regeneration in ischemic area of rats with [31] Yan WW, Li GH, Jia YM, et al. Effects of paeoniflorin on
cerebral ischemia-reperfusion[J]. Chin J Integr Med Cardio apoptosis and bcl-2/bax protein expression in hippocampal neu-
Cerebrovasc Dis (中西医结合心脑血管病杂志), 2021, 19(16): rons induced by lead acetate[J]. Chin J Mod Appl Pharm (中国
2757-2763. 现代应用药学), 2022, 39(6): 730-737.