Page 122 - 《中国药科大学学报》2025年第5期

学报
654 Journal of China Pharmaceutical University 2025, 56(5): 654 − 660

真空压缩成型技术在药剂学中的研究进展

王亦玄 ，陈 鑫 ，何 莲 ，张聪聪 ，沈佩亚 ，高 缘 ，张建军 1*
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（ 中国药科大学药学院, 南京 211198； 浙江永宁药业股份有限公司, 台州 318020； 中国药科大学中药学院, 南京 211198）
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摘 要 真空压缩成型技术是一种辅助药物固体分散体研发的新技术，其因制备样品的便捷性与准确性而被广泛应用。该
设备结合加热熔融冷却和真空压缩的原理将固体粉末直接制备成具有一定形状的固体，并可通过选用不同的模具和调控温
度及压力获得不同特性的样品。本文介绍了真空压缩成型技术的设备组成及工作原理，通过对比热熔挤出技术，运用案例分
析说明真空压缩成型技术在无定形固体分散体处方工艺筛选的独特优势，介绍了其在药物递送系统及流变表征分析样品的
构建上的应用，并对其未来的功能开发进行展望。
关键词 真空压缩成型；无定形固体分散体；药物递送系统；热熔挤出；表征分析
中图分类号 R943 文献标志码 A 文章编号 1000−5048(2025)05−0654−07
doi：10.11665/j.issn.1000−5048.2024070303

引用本文 王亦玄，陈鑫，何莲，等. 真空压缩成型技术在药剂学中的研究进展 [J]. 中国药科大学学报，2025，56（5）：654 − 660.

Cite this article as: WANG Yixuan, CHEN Xin, HE Lian, et al. Research progress of vacuum compression molding technology in
pharmaceutical fields[J]. J China Pharm Univ, 2025, 56(5): 654 − 660.

Research progress of vacuum compression molding technology in

pharmaceutical fields
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WANG Yixuan , CHEN Xin , HE Lian , ZHANG Congcong , SHEN Peiya , GAO Yuan , ZHANG Jianjun 1*
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School of Pharmacy, China Pharmaceutical University, Nanjing 211198; Zhejiang Yongning Pharmaceutical Co., Ltd., Taizhou
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318020; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Abstract Vacuum compression molding (VCM) is a novel technology supporting the research and development
of pharmaceutical solid dispersions. It is widely applied due to its precision and convenience in sample
preparation. This technology integrates the principles of heating, melting, cooling, and vacuum compression to
transform solid powders into shaped solids directly. By selecting different molds, temperatures, and pressures,
researchers can prepare samples with diverse characteristics. This paper presents an overview of the equipment
composition and working principles of VCM technology, demonstrating its distinct advantages in the formulation
screening process of amorphous solid dispersions through comparative analysis with hot melt extrusion using
case studies, and introduces its applications in the development of drug delivery systems and rheological
characterization analysis, with a perspective on the future development of its functions.
Key words vacuum compression molding; amorphous solid dispersions; drug delivery system; hot melt
extrusion; characterization analysis

This study was supported by the National Natural Science Foundation of China (No.82074029; No.82373824; No.82474088)

真空压缩成型（vacuum compression molding， 空和加热将微量固体粉末快速制备成具有一定形
VCM）技术是一种基于“熔融-冷却”原理，通过抽真 状固体的新技术，具有操作简单、用量少（毫克级到

收稿日期 2024-07-03 * 通信作者 Tel：13951974969 E-mail：myamicute@163.com
基金项目 国家自然科学基金项目 （No.82074029, No.82373824, No.82474088）