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第 56 卷第 5 期 徐嘉荇,等:血管内皮细胞衰老与心血管疾病的相关性及药物治疗策略 653
with an immune cascade effect for inhibiting tissue fibrosis[J]. with cardiac pathology[J]. Cardiovasc Res, 2024, 120(5): 506-
Acta Biomater, 2023, 171: 308-326. 518.
[33] Raslan AA, Pham TX, Lee JS, et al. Lung injury-induced acti- [49] Inci N, Kamali D, Akyildiz EO, et al. Translation of cellular
vated endothelial cell states persist in aging-associated progres- senescence to novel therapeutics: insights from alternative tools
sive fibrosis[J]. Nat Commun, 2024, 15(1): 5449. and models[J]. Front Aging, 2022, 3: 828058.
[34] Yang P, Wu YJ, Li FF, et al. Activation of ETAR and ETBR in [50] Belakova B, Wedige NK, Awad EM, et al. Lipophilic statins
myocardial tissue characterizes heart failure induced by experi- eliminate senescent endothelial cells by inducing anoikis-relat-
mental autoimmune myocarditis[J]. BMC Cardiovasc Disord, ed cell death[J]. Cells, 2023, 12(24): 2836.
2024, 24(1): 11. [51] Neves MF, Cunha AR, Cunha MR, et al. The role of renin-an-
[35] Wang Y, Yu J, Ou CX, et al. miRNA-146a-5p inhibits hypoxia- giotensin-aldosterone system and its new components in arteri-
induced myocardial fibrosis through EndMT[J]. Cardiovasc al stiffness and vascular aging[J]. High Blood Press Cardiovasc
Toxicol, 2024, 24(2): 133-145. Prev, 2018, 25(2): 137-145.
[36] Li Z, Xia HJ, Sharp TE 3rd, et al. Hydrogen sulfide modulates [52] Nguyen TD, Rao MK, Dhyani SP, et al. Nucleoporin93 limits
endothelial-mesenchymal transition in heart failure[J]. Circ Res, Yap activity to prevent endothelial cell senescence[J]. Aging
2023, 132(2): 154-166. Cell, 2024, 23(4): e14095.
[37] Deng FY, Xie LY, Zhan SB et al. Endothelial to mesenchymal
[53] Rios Coronado PE, Zhou JY, Fan XC, et al. CXCL12 drives
transition participates in doxorubicin induced rat myocardial fi-
natural variation in coronary artery anatomy across diverse pop-
brosis[J]. Basic Clin Med(基础医学与临床), 2018, 38(9):
ulations[J]. Cell, 2025, 188(7): 1784-1806. e22.
1251-1257.
[54] Zuo DY, Wang M, Shen P, et al. Research progress on tradi-
[38] Duangrat R, Parichatikanond W, Likitnukul S, et al. Endothelin-
tional Chinese medicine in prevention and treatment of vascular
1 induces cell proliferation and myofibroblast differentiation
endothelial dysfunction[J]. Chin Tradit Herb Drugs (中草药),
through the ET A R/g αq /ERK signaling pathway in human car-
2025, 56(1): 340-348.
diac fibroblasts[J]. Int J Mol Sci, 2023, 24(5): 4475.
[55] Ye CB, Chen XY, Du JY, et al. Effect of Buyang Huanwu de-
[39] de Montgolfier O, Pinçon A, Pouliot P, et al. High systolic
coction on delaying vascular aging based on miR-665/DRAM1
blood pressure induces cerebral microvascular endothelial dys-
signaling-mediated autophagy[J]. J Nanjing Univ Tradit Chin
function, neurovascular unit damage, and cognitive decline in
Med(南京中医药大学学报), 2024, 40(4): 369-378.
mice[J]. Hypertension, 2019, 73(1): 217-228.
[56] Chen MT, Zhong GF, Liu MN, et al. Integrating network analy-
[40] Born E, Lipskaia L, Breau M, et al. Eliminating senescent cells
sis and experimental validation to reveal the mitophagy-associ-
can promote pulmonary hypertension development and progres-
ated mechanism of Yiqi Huoxue (YQHX) prescription in the
sion[J]. Circulation, 2023, 147(8): 650-666.
treatment of myocardial ischemia/reperfusion injury[J]. Phar-
[41] Culley MK, Zhao JS, Tai YY, et al. Frataxin deficiency pro-
macol Res, 2023, 189: 106682.
motes endothelial senescence in pulmonary hypertension[J]. J
[57] Xiu CK, Fu YK, Wang Q, et al. Mechanism of extract of Gin-
Clin Invest, 2021, 131(11): e136459.
seng Radix et Rhizoma, Notoginseng Radix et Rhizoma and
[42] Gevaert AB, Shakeri H, Leloup AJ, et al. Endothelial senes-
Chuanxiong Rhizoma on SIRT1 autophagy pathway of endothe-
cence contributes to heart failure with preserved ejection frac-
lial cell senescence induced by hydrogen peroxide[J]. China J
tion in an aging mouse model[J]. Circ Heart Fail, 2017, 10(6):
Chin Mater Med(中国中药杂志), 2021, 46(23): 6216-6223.
e003806.
[58] Lee GH, Hoang TH, Jung ES, et al. Anthocyanins attenuate en-
[43] Riehle C, Bauersachs J. Small animal models of heart failure[J].
dothelial dysfunction through regulation of uncoupling of nitric
Cardiovasc Res, 2019, 115(13): 1838-1849.
oxide synthase in aged rats[J]. Aging Cell, 2020, 19(12):
[44] Yoshida Y, Shimizu I, Katsuumi G, et al. p53-Induced inflam-
mation exacerbates cardiac dysfunction during pressure over- e13279.
load[J]. J Mol Cell Cardiol, 2015, 85: 183-198. [59] Wu Q,Li HM,Yang CK, et al. Research progress on cardiovas-
[45] Jesel L, Abbas M, Park SH, et al. Atrial fibrillation progression cular protective mechanism of resveratrol[J]. China J Chin
is associated with cell senescence burden as determined by p53 Mater Med (中国中药杂志), 2025, 50(12): 3244-3251.
and p16 expression[J]. J Clin Med, 2019, 9(1): 36. [60] Chen YT, Wang ST, Yang SJ, et al. Inhibitory role of ginseno-
[46] Hasan H, Park SH, Auger C, et al. Thrombin induces an- side Rb2 in endothelial senescence and inflammation mediated
giotensin II-mediated senescence in atrial endothelial cells: im- by microRNA-216a[J]. Mol Med Rep, 2021, 23(6): 415.
pact on pro-remodeling patterns[J]. J Clin Med, 2019, 8(10): [61] Wang K, Wang Y, Peng F, et al. The protective effect of evodi-
1570. amine on Ang Ⅱ-induced endothelial cell senescence regulated
[47] Zhang L, Pitcher LE, Prahalad V, et al. Targeting cellular senes- by endothelial microparticles[J]. Chin Pharmacol Bull (中国药
cence with senotherapeutics: senolytics and senomorphics[J]. 理学通报), 2024, 40(11): 2199-2200.
FEBS J, 2023, 290(5): 1362-1383. [62] Zhang L, Liu LS, Wang MY. Effects of puerarin on chronic in-
[48] Mehdizadeh M, Naud P, Abu-Taha IH, et al. The role of cellu- flammation: focus on the heart, brain, and arteries[J]. Aging
lar senescence in profibrillatory atrial remodelling associated Med (Milton), 2021, 4(4): 317-324.

