Page 127 - 《中国药科大学学报》2025年第5期

第 56 卷第 5 期 王亦玄，等：真空压缩成型技术在药剂学中的研究进展 659

流变学测试 其他应用

溶解度
黏度测定:
v v
剪切
均匀样品 含气泡样品 植入剂 差示扫描量热法
熔体拉伸试验:
均匀样品 常规形状的片剂
拉伸 粉末X射线衍射
含气泡样品
发生断裂 异形片剂 …
图 2 VCM 技术在制剂表征与检测中的应用
5 总结与展望 导报) 2023, 42(7): 984-988.
[7] Turpin ER, Taresco V, Al-Hachami WA, et al. In silico screen-
本文介绍了 VCM 技术的制备原理和优缺点 ing for solid dispersions: the trouble with solubility parameters
以及在药剂学中的应用进展。通过对比 HME 技 and χFH[J]. Mol Pharm, 2018, 15(10): 4654-4667.
[8] Meng F, Trivino A, Prasad D, et al. Investigation and correla-
术，运用案例分析说明 VCM 技术在 ASD 前期开发 tion of drug polymer miscibility and molecular interactions by
中处方工艺筛选的独特优势（物料用量少、样品制 various approaches for the preparation of amorphous solid dis-
备快速、清洗方便等），并介绍了其在药物递送系统 persions[J]. Eur J Pharm Sci, 2015, 71: 12-24.
[9] Lauer ME, Maurer R, Paepe AT, et al. A miniaturized extruder
和表征样品构建上的应用。然而，VCM 技术仍具
to prototype amorphous solid dispersions: selection of plasticiz-
有一定的局限性，它除了主要替代 HME 筛选载体 ers for hot melt extrusion[J]. Pharmaceutics, 2018, 10(2): 58.
外，在其他制剂应用方面案例较少，还不成熟。此 [10] Hörmann TR, Jäger N, Funke A, et al. Formulation perfor-
外，该技术目前还无法做到全自动化放大生产，其 mance and processability window for manufacturing a dual-
polymer amorphous solid dispersion via hot-melt extrusion and
在先进药物给药系统工业化开发方面的技术价值 strand pelletization[J]. Int J Pharm, 2018, 553(1/2): 408-421.
尚未充分体现，未来还需对 VCM 设备进行技术升 [11] Pöstges F, Kayser K, Stoyanov E, et al. Boost of solubility and
级，更好地应用于高端复杂制剂产品的开发。 supersaturation of celecoxib via synergistic interactions of
methacrylic acid-ethyl acrylate copolymer (1∶1) and hydrox-
ypropyl cellulose in ternary amorphous solid dispersions[J]. Int
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