Page 113 - 《中国药科大学学报》2025年第5期

学报
Journal of China Pharmaceutical University 2025, 56(5): 645 − 653 645

·综 述·

血管内皮细胞衰老与心血管疾病的相关性及药物治疗策略

徐嘉荇，李雯婷，劳嘉怡，刘 康 *

（中国药科大学中药学院中药药理与中医药学系, 南京 211198）

摘 要 血管老化是人体衰老的关键诱发因素，也是动脉粥样硬化（atherosclerosis，AS）、心肌纤维化、高血压等发生发展过
程中的病理基础。研究认为，血管老化是机体衰老的始动环节，而细胞衰老是血管老化的重要机制。血管老化的过程主要涉
及内皮细胞（endothelial cells，ECs）和平滑肌细胞的衰老。因此，本文围绕与 ECs 衰老有关的端粒功能障碍、氧化应激、代
谢紊乱等相关分子机制展开，阐述了 ECs 衰老与血管功能障碍、AS、心肌纤维化、高血压等心血管疾病（cardiovascular
diseases，CVDs）发展的相关性，同时系统总结西药、中药复方及单体的相关治疗策略，以期为后续治疗与研究提供理论参考。
关键词 心血管疾病；内皮细胞；细胞衰老；中药
中图分类号 R972 文献标志码 A 文章编号 1000−5048(2025)05−0645−09
doi：10.11665/j.issn.1000−5048.2025030701

引用本文 徐嘉荇，李雯婷，劳嘉怡，等. 血管内皮细胞衰老与心血管疾病的相关性及药物治疗策略 [J]. 中国药科大学学报，2025，56（5）：
645 − 653.

Cite this article as: XU Jiaxing, LI Wenting, LAO Jiayi, et al. Relevance of vascular endothelial cell senescence to cardiovascular diseases and
pharmacotherapeutic strategy[J]. J China Pharm Univ, 2025, 56(5): 645 − 653.

Relevance of vascular endothelial cell senescence to cardiovascular
diseases and pharmacotherapeutic strategy

XU Jiaxing, LI Wenting, LAO Jiayi, LIU Kang *
Department of Traditional Chinese Medicine Pharmacology and Traditional Chinese Medicine, School of Traditional Chinese
Pharmacy, China Pharmaceutical University, Nanjing 211198,China

Abstract Vascular aging plays a key role in the induction of human aging and serves as the pathological basis
for the occurrence and development of atherosclerosis (AS), myocardial fibrosis, and hypertension. Research
suggests that vascular aging is the initiating link in the aging process of the body, and cellular senescence is a key
mechanism of vascular aging. The process of vascular aging mainly involves the senescence of endothelial cells
(ECs) and smooth muscle cells. This review, therefore, focuses on the molecular mechanisms related to telomere
dysfunction, oxidative stress, and metabolic disorders involved in senescence of ECs, elaborating on the
correlation between the senescence of endothelial cells and the development of vascular dysfunction, AS,
myocardial fibrosis, hypertension, and other cardiovascular diseases (CVDs), and at the same time, systematically
summarizes the relevant treatment strategies with western medicines, traditional Chinese medicine formulas, and
monomers, to provide some theoretical reference for subsequent treatment and research.
Key words cardiovascular disease; endothelial cell; cellular senescence; traditional Chinese medicine

The study was supported by the National Natural Science Foundation of China (No.82174009)

[1]
衰老作为一种不可抗拒的自然规律，是机体随 程，可导致机体退行性疾病的发生和加剧 。越来
着年龄增长所出现的功能性和器质性衰老退化过 越多的国家进入人口老龄化阶段，伴随而来的是老

收稿日期 2025-03-07 * 通信作者 Tel：13912979427 E-mail：liukangcpu@aliyun.com
基金项目 国家自然科学基金项目（No.82174009）