Page 112 - 《中国药科大学学报》2025年第5期
P. 112

644                      学报   Journal of China Pharmaceutical University 2025, 56(5): 634 − 644  第 56 卷

                    2015, 407(16): 4683-4695.                   [26]   DeVore  NM,  Scott  EE.  Structures  of  cytochrome  P450  17A1
               [18]   Hanna AY, Abbas H, Yassine F, et al. Systematic review of gut  with prostate cancer drugs abiraterone and TOK-001[J]. Nature,
                    microbiota composition, metabolic alterations, and the effects of  2012, 482(7383): 116-119.
                    treatments on PCOS and gut microbiota across human and ani-  [27]   Grimshaw RN, Mitchell BF, Challis JR. Steroid modulation of
                    mal studies[J]. Front Microbiol, 2025, 16: 1549499.  pregnenolone  to  progesterone  conversion  by  human  placental
               [19]   Yu Y, Tan PL, Zhuang ZC, et al. Untargeted metabolomic ap-  cells in vitro[J]. Am J Obstet Gynecol, 1983, 145(2): 234-238.
                    proach to study the serum metabolites in women with polycys-  [28]   Vanweert  F,  Schrauwen  P,  Phielix  E.  Role  of  branched-chain
                    tic ovary syndrome[J]. BMC Med Genomics, 2021, 14(1): 206.  amino acid metabolism in the pathogenesis of obesity and type
               [20]   Salilew-Wondim D, Wang Q, Tesfaye D, et al. Polycystic ovari-  2 diabetes-related metabolic disturbances BCAA metabolism in
                                                                     type 2 diabetes[J]. Nutr Diabetes, 2022, 12(1): 35.
                    an syndrome is accompanied by repression of gene signatures
                                                                [29]   Kogot-Levin  A,  Riahi  Y,  Abramovich  I,  et  al.  Mapping  the
                    associated with biosynthesis and metabolism of steroids, choles-
                                                                     metabolic reprogramming induced by sodium-glucose cotrans-
                    terol and lipids[J]. J Ovarian Res, 2015, 8: 24.
                                                                     porter 2 inhibition[J]. JCI Insight, 2023, 8(7): e164296.
               [21]   Cho LW, Sathyapalan T, Kilpatrick ES, et al. Androsterone glu-
                                                                [30]   Wang M, Zhang BQ, Ma S, et al. Broadening horizons: the role
                    curonide to dehydroepiandrosterone sulphate ratio is discrimina-
                                                                     of  ferroptosis  in  polycystic  ovary  syndrome[J].  Front  En-
                    tory for  obese  Caucasian  women  with  polycystic  ovary   syn-
                                                                     docrinol (Lausanne), 2024, 15: 1390013.
                    drome[J]. BMC Endocr Disord, 2017, 17(1): 26.
                                                                [31]   Tian Y, Zhang W, Zhao SG, et al. FADS1-FADS2 gene cluster
               [22]   Wang  KX,  Li  YH,  Chen  Y.  Androgen  excess:  a  hallmark  of
                                                                     confers risk to polycystic ovary syndrome[J]. Sci Rep, 2016, 6:
                    polycystic  ovary  syndrome[J].  Front  Endocrinol  (Lausanne),
                                                                     21195.
                    2023, 14: 1273542.
                                                                [32]   Olaniyi KS, Okara DO, Areloegbe SE. Suppression of adipose
               [23]   Dong JW, Aled Rees D. Polycystic ovary syndrome: pathophys-
                                                                     TGF-β1 by probiotics alleviates metabolic disturbance in exper-
                    iology and therapeutic opportunities[J]. BMJ Med, 2023, 2(1):
                                                                     imentally induced PCOS[J]. Prostaglandins Other Lipid Medi-
                    e000548.                                         at, 2025, 178: 106989.
               [24]   Armstrong CM, Gao AC. Dysregulated androgen synthesis and  [33]   Zhang WY, Wu FJ. Linoleic acid induces human ovarian granu-
                    anti-androgen  resistance  in  advanced  prostate  cancer[J].  Am  J  losa cell inflammation and apoptosis through the ER-FOXO1-
                    Clin Exp Urol, 2021, 9(4): 292-300.              ROS-NFκB pathway[J]. Sci Rep, 2024, 14(1): 6392.
               [25]   Giatromanolaki A, Fasoulaki V, Kalamida D, et al. CYP17A1  [34]   Puchałowicz K, Rać ME. The multifunctionality of CD36 in di-
                    and androgen-receptor expression in prostate carcinoma tissues  abetes  mellitus  and  its  complications-update  in  pathogenesis,
                    and cancer cell lines[J]. Curr Urol, 2019, 13(3): 157-165.  treatment and monitoring[J]. Cells, 2020, 9(8): 1877.
   107   108   109   110   111   112   113   114   115   116   117