Page 108 - 《渔业研究》2025年第5期

第 5 期 穆志新等： 大牡蛎弧菌 S2 胶原酶基因的克隆、表达及其对菲律宾蛤仔基因表达的调控 649

［14］ Defoirdt T. Virulence mechanisms of bacterial aquacul- Apostichopus japonicus[J]. Aquaculture, 2023, 571:
ture pathogens and antivirulence therapy for aquacultu- 739489.
re[J]. Reviews in Aquaculture, 2014, 6(2): 100 − 114. ［26］ Dai H J, Shi W B, Li Y, et al. Characterization of ColA
［15］ Teo J W P, Zhang L H, Poh C L. Cloning and character- as a virulence factor of Vibrio alginolyticus H1 patho-
ization of a metalloprotease from Vibrio harveyi strain genic to cuttlefish Sepia pharaonis[J]. Aquaculture, 2025,
AP6[J]. Gene, 2003, 303: 147 − 156. 607: 742654.
［16］ Harrington D J. Bacterial collagenases and collagen-de- ［27］ Zhang W W, Sun L. Cloning, characterization, and mo-
grading enzymes and their potential role in human dis- lecular application of a beta-agarase gene from Vibrio sp.
ease[J]. Infection and Immunity, 1996, 64(6): 1885 − strain V134[J]. Applied and Environmental Microbio-
1891. logy, 2007, 73(9): 2825 − 2831.
［17］ Rawlings N D, Waller M, Barrett A J, et al. MEROPS: ［28］ Yan L J, Jin T C, Chen Y L, et al. Characterization of a
the database of proteolytic enzymes, their substrates and
recombinant matrix metalloproteinase-2 from sea cucum-
inhibitors[J]. Nucleic Acids Research, 2014, 42(D1):
ber (Stichopus japonicas) and its application to prepare
D503 − D509.
bioactive collagen hydrolysate[J]. Process Biochemistry,
［18］ Lee J H, Ahn S H, Lee E M, et al. Characterization of the
2018, 72: 63 − 70.
enzyme activity of an extracellular metalloprotease (VMC)
［29］ 贾玲玲，万乾炳. 基质金属蛋白酶抑制剂的研究进展 [J].
from Vibrio mimicus and its C-terminal deletions[J].
华西口腔医学杂志，2017，35（2） ：208 − 214.
FEMS Microbiology Letters, 2003, 223(2): 293 − 300.
Jia L L, Wan Q B. Progress on matrix metalloproteinase
［19］ Lee J H, Kim G T, Lee J Y, et al. Isolation and sequence
inhibitors[J]. West China Journal of Stomatology, 2017,
analysis of metalloprotease gene from Vibrio mimicus[J].
35(2): 208 − 214.
Biochimica et Biophysica Acta (BBA)-Protein Structure
［30］ Duarte A S, Correia A, Esteves A C. Bacterial colla-
and Molecular Enzymology, 1998, 1384(1): 1 − 6.
genases—a review[J]. Critical Reviews in Microbiology,
［20］ Takeuchi H, Shibano Y, Morihara K, et al. Structural
2016, 42(1): 106 − 126.
gene and complete amino acid sequence of Vibrio al-
［31］ Moreira R, Balseiro P, Planas J V, et al. Transcriptomics
ginolyticus collagenase[J]. Biochemical Journal, 1992,
of in vitro immune-stimulated hemocytes from the Ma-
281(3): 703 − 708.
nila clam Ruditapes philippinarum using high-through-
［21］ Milton D L, Norqvist A, Wolf-Watz H. Cloning of a
put sequencing[J]. PLoS One, 2012, 7(4): e35009.
metalloprotease gene involved in the virulence mechan-
［32］ Li S K, Nie H T, Huo Z M, et al. Transcriptomic signa-
ism of Vibrio anguillarum[J]. Journal of Bacteriology,
tures related to the immune priming of Ruditapes philip-
1992, 174(22): 7235 − 7244.
［22］ Miyoshi S, Kawata K, Tomochika K, et al. The C-ter- pinarum in response to the re-infection of Vibrio anguil-
larum[J]. Fish & Shellfish Immunology, 2025, 161:
minal domain promotes the hemorrhagic damage caused
110263.
by Vibrio vulnificus metalloprotease[J]. Toxicon, 2001,
［33］ Saeed M B, Record J, Westerberg L S. Two sides of the
39(12): 1883 − 1886.
［23］ Galvis F, Barja J L, Lemos M L, et al. The vibriolysin- coin: cytoskeletal regulation of immune synapses in can-
like protease VnpA and the collagenase ColA are re- cer and primary immune deficiencies[J]. International
quired for full virulence of the bivalve mollusks patho- Review of Cell and Molecular Biology, 2020, 356: 1 − 97.
gen Vibrio neptunius[J]. Antibiotics, 2021, 10(4): 391. ［34］ Ljubojević Pelić D, Radosavljević V, Pelić M, et al. An-
［24］ Yishan L, Jiaming F, Zaohe W, et al. Genotype analysis tibiotic residues in cultured fish: implications for food
of collagenase gene by PCR-SSCP in Vibrio alginolytic- safety and regulatory concerns[J]. Fishes, 2024, 9(12):
us and its association with virulence to marine fish[J]. 484.
Current Microbiology, 2011, 62(6): 1697 − 1703. ［35］ Defoirdt T. Antivirulence therapy for animal production:
［25］ Li Y, Yang H R, Zhang J X, et al. VspC from Vibrio filling an arsenal with novel weapons for sustainable dis-
splendidus is responsible for collagen degradation in ease control[J]. PLoS Pathogens, 2013, 9(10): e1003603.