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刘绵宇,等 水产学报, 2023, 47(1): 019417
括 Metafounders 的 H 矩阵,可以进一步追溯祖先 molyticus as the causative agent of acute hepatopancre-
[29]
个体 ,更好地刻画个体间的亲缘关系 ,减少 atic necrosis disease of cultured shrimp (Litopenaeus
[30]
[19]
加性遗传方差与随机残差方差的混淆 ,从而获 vannamei) in Northwestern Mexico[J]. Applied and
[4]
得更高的遗传力估计值。Wang 等 利用基因组信 Environmental Microbiology, 2015, 81(5): 1689-1699.
息获得凡纳滨对虾 Vp D 侵染后存活状态的遗
AHPN [ 4 ] Wang Q C, Yu Y, Zhang Q, et al. Evaluation on the gen-
传力估计值为 0.16±0.09,略低于本研究结果。这 omic selection in Litopenaeus vannamei for the resist-
可能是由于本研究中 3 个奠基者群体遗传和表型 ance against Vibrio parahaemolyticus[J]. Aquaculture,
性能差异大,携带相对较多与 AHPND 抗性相关
2019, 505: 212-216.
的有利等位基因,从而导致加性遗传变异丰富。
[ 5 ] Legarra A, Christensen O F, Vitezica Z G, et al. Ances-
对于其他病原如桃拉病毒 (TSV) 和白斑综合征病
tral relationships using metafounders: Finite ancestral
毒 (WSSV) 抗性,利用不同的育种群体和分析模
populations and across population relationships[J].
型,获得的遗传估计值变化范围较大 (0.03±0.02~
Genetics, 2015, 200(2): 455-468.
0.28±0.14),表现为中低等遗传力水平 [31-32] 。
[ 6 ] Garcia-Baccino C A, Legarra A, Christensen O F, et al.
4 结论 Metafounders are related to F st fixation indices and
reduce bias in single-step genomic evaluations[J]. Genet-
本研究首次利用液相芯片“黄海芯 1 号”提供 ics Selection Evolution, 2017, 49(1): 34.
的高通量 SNP 分型信息,准确地刻画出 3 个奠基 [ 7 ] Rengmark A H, Slettan A, Skaala Ø, et al. Genetic vari-
者群体及个体间的亲缘关系;发现 3 个群体的遗 ability in wild and farmed Atlantic salmon (Salmo salar)
传多样性水平存在显著差异;构建了个体间的基 strains estimated by SNP and microsatellites[J].
因组亲缘关系矩阵,筛查出近交水平较高的部分 Aquaculture, 2006, 253(1-4): 229-237.
群体及个体;查明了基础群体 Vp AHPN D 侵染后存 [ 8 ] Wenne R, Bernaś R, Kijewska A, et al. SNP genotyping
活状态的遗传力为中等水平,相关研究结果为后 reveals substructuring in weakly differentiated popula-
续育种方案设计和育种群体构建提供了关键的技 tions of Atlantic cod (Gadus morhua) from diverse
术参数支持。 environments in the Baltic Sea[J]. Scientific Reports,
2020, 10(1): 9738.
(作者声明本文无实际或潜在的利益冲突) [ 9 ] Correa K, Lhorente J P, Bassini L, et al. Genome wide
association study for resistance to Caligus rogercresseyi
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