Page 129 - 《中国药科大学学报》2026年第2期

许译尹，等：吲哚布芬通过抑制 NF-κB/Caspase-1/GSDMD 通路减轻脑缺血再灌注损伤的作用
第 57 卷第 2 期 与机制研究 255

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预中均能通过抑制细胞焦亡显著减轻脑 I/R 损伤， occlusion: evaluation of the model and development of a neuro-
并促进模型动物的长期记忆巩固、空间学习能力及 logic examination[J]. Stroke, 1986, 17(3): 472-476.
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认知功能重建。机制研究表明，其神经保护作用与 covery of neurological and motor function in rats after cerebral
调控焦亡关键通路 NF-κB/Caspase-1/GSDMD 信号 ischemic injury through inhibiting Notch/NF-κB pathway[J]. J
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力，为缺血性脑卒中的临床转化研究提供了新型候 genesis in a Wnt/β-catenin signaling dependent way[J]. Life Sci,
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