Page 24 - 《中国药科大学学报》2026年第1期

18 学报 Journal of China Pharmaceutical University 2026, 57(1): 11 − 18 第 57 卷

604. cov Today, 2021, 26(5): 1256-1264.
[48] Oprişoreanu AM, Smith HL, Krix S, et al. Automated in vivo [56] Dimitsaki S, Natsiavas P, Jaulent MC. Applying AI to struc-
drug screen in zebrafish identifies synapse-stabilising drugs tured real-world data for pharmacovigilance purposes: scoping
with relevance to spinal muscular atrophy[J]. Dis Model Mech, review[J]. J Med Internet Res, 2024, 26: e57824.
2021, 14(4): dmm047761. [57] Liu RQ, Wei L, Zhang P. A deep learning framework for drug
[49] Lin SA, Schorpp K, Rothenaigner I, et al. Image-based high- repurposing via emulating clinical trials on real-world patient
content screening in drug discovery[J]. Drug Discov Today,
data[J]. Nat Mach Intell, 2021, 3(1): 68-75.
2020, 25(8): 1348-1361.
[58] Jarallah SJ, Almughem FA, Alhumaid NK, et al. Artificial intel-
[50] Berg EL. The future of phenotypic drug discovery[J]. Cell
ligence revolution in drug discovery: a paradigm shift in phar-
Chem Biol, 2021, 28(3): 424-430.
maceutical innovation[J]. Int J Pharm, 2025, 680: 125789.
[51] Braga L, Ali H, Secco I, et al. Drugs that inhibit TMEM16 pro-
[59] van der Pol KH, Aljofan M, Blin O, et al. Drug repurposing of
teins block SARS-CoV-2 spike-induced syncytia[J]. Nature,
generic drugs: challenges and the potential role for
2021, 594(7861): 88-93.
government[J]. Appl Health Econ Health Policy, 2023, 21(6):
[52] Gns HS, Gr S, Murahari M, et al. An update on drug repurpos-
831-840.
ing: re-written Saga of the drug’s fate[J]. Biomed Pharma-
[60] Maier A, Hartung M, Abovsky M, et al. Drugst. One - a plug-
cother, 2019, 110: 700-716.
and-play solution for online systems medicine and network-
[53] Davidson KW, Barry MJ, Mangione CM, et al. Aspirin use to
based drug repurposing[J]. Nucleic Acids Res, 2024, 52(W1):
prevent cardiovascular disease: us preventive services task force
W481-W488.
recommendation statement[J]. JAMA, 2022, 327(16): 1577-
[61] Kamya P, Ozerov IV, Pun FW, et al. PandaOmics: an AI-driv-
1584.
[54] Liu F, Panagiotakos D. Real-world data: a brief review of the en platform for therapeutic target and biomarker discovery[J]. J
methods, applications, challenges and opportunities[J]. BMC Chem Inf Model, 2024, 64(10): 3961-3969.
Med Res Methodol, 2022, 22(1): 287. [62] Sadegh S, Skelton J, Anastasi E, et al. Network medicine for
[55] Chen ZY, Liu X, Hogan W, et al. Applications of artificial intel- disease module identification and drug repurposing with the Ne-
ligence in drug development using real-world data[J]. Drug Dis- DRex platform[J]. Nat Commun, 2021, 12(1): 6848.