Page 121 - 《中国药科大学学报》2026年第1期

学报
Journal of China Pharmaceutical University 2026, 57(1): 115 − 121 115

黄蜀葵花及其黄酮类活性成分治疗糖尿病肾病的作用及机制

余怡虹 ，李 楠 ，吴 洁 1*
1
2
1
（ 中国药科大学生命科学与技术学院, 南京 211100； 南京中医药大学附属江苏省中医院内分泌科, 南京 210029）
2
摘 要 黄蜀葵作为传统中药，其干燥花冠以“利尿通淋、消肿解毒”功效广泛应用于糖尿病肾病（diabetic nephropathy,
DN）等肾脏疾病的治疗。近年来的研究表明，黄蜀葵花 Abelmoschi Corolla 的核心活性成分为黄酮类化合物，主要包括芦
丁、金丝桃苷、异槲皮素、棉皮素-8-O-β-D-葡萄糖醛酸苷、杨梅素、槲皮素 3-O-β-D-葡糖苷酸和槲皮素等 7 种特征性成分。这
些黄酮成分可通过多靶点协同机制干预 DN 病理进程，并有效降低尿蛋白水平。本文综述了黄蜀葵花及其黄酮类成分在调
控 DN 关键病理环节及相关机制方面的作用，并简要探讨了其活性成分的代谢规律以及联合用药的研究进展，旨在为深入研
究黄蜀葵花治疗 DN 的分子机制及临床应用提供前瞻性的科学依据。
关键词 黄蜀葵花；糖尿病肾病；黄酮类化合物；机制
中图分类号 R285 文献标志码 A 文章编号 1000−5048(2026)01−0115−07
doi：10.11665/j.issn.1000−5048.2025031701

引用本文 余怡虹，李楠，吴洁. 黄蜀葵花及其黄酮类活性成分治疗糖尿病肾病的作用及机制 [J]. 中国药科大学学报，2026，57（1）：115-
121.

Cite this article as: YU Yihong, LI Nan, WU Jie. Effects and molecular mechanisms of Abelmoschi Corolla and its active flavonoids in the
treatment of diabetic nephropathy[J]. J China Pharm Univ, 2026, 57(1): 115-121.

Effects and molecular mechanisms of Abelmoschi Corolla and its active
flavonoids in the treatment of diabetic nephropathy

1
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YU Yihong , LI Nan , WU Jie 1*
1 2
School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198; Department of Endocrinology, The
Affiliated Jiangsu Provincial Hospital of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China
Abstract Abelmoschi Corolla is extensively applied in managing diabetic nephropathy (DN) and other renal
conditions due to its diuretic and detoxifying properties. The primary bioactive constituents of Abelmoschi
Corolla are flavonoids, including notably rutin, hyperoside, isoquercitrin, hibifolin, myricetin, quercetin 3-O-β-D-
glucuronide, and quercetin. These flavonoid components can influence the pathological progression of DN via a
multi-target synergistic mechanism, effectively reducing proteinuria levels. This review examines the roles of
Abelmoschi Corolla and its flavonoid components in modulating the key pathological aspects of DN and their
underlying mechanisms, and briefly discusses the metabolic patterns of its bioactive components and the research
progress in combined medication, aiming to provide a forward-looking scientific foundation for further
investigating the molecular mechanisms and clinical applications of Abelmoschi Corolla in DN treatment.
Key words Abelmoschi Corolla; diabetic nephropathy; flavonoid; mechanism

This study was supported by the National Natural Science Foundation of China (No.82104751)

糖尿病肾病（diabetic nephropathy, DN）是糖尿 病患者会发展为 DN 。作为一种典型的慢性进行
[1]
病的微血管并发症之一，全球约 30% ~ 40% 的糖尿 性疾病，DN 的核心病理生理特征表现为肾小球滤

收稿日期 2025-03-17 * 通信作者 E-mail：wujie@cpu.edu.cn
基金项目 国家自然科学基金项目 (No.82104751)