Page 63 - 《中国药科大学学报》2025年第4期

第 56 卷第 4 期 陈 果，等：积雪草酸衍生物的合成及抗肿瘤活性测定 459

3 结 语 tions[J]. Curr Top Med Chem, 2022, 22(11): 891-920.
[7] Wey JS, Stoeltzing O, Ellis LM. Vascular endothelial growth
初步的构效关系研究表明，C-2, C-3, C-23 位 factor receptors: expression and function in solid tumors[J]. Clin
羟基进行酯化和甲基化，C-28 位羧基酰胺化，对其 Adv Hematol Oncol, 2004, 2(1): 37-45.
[8] Zhao YS, Guo SP, Deng J, et al. VEGF/VEGFR-targeted thera-
抗肿瘤活性具有提高作用；MTT 结果显示修饰后的 py and immunotherapy in non-small cell lung cancer: targeting
衍生物具有一定的抑制肿瘤细胞增殖的能力。这 the tumor microenvironment[J]. Int J Biol Sci, 2022, 18(9):
对积雪草酸进一步结构修饰及优化具有一定的参 3845-3858.
[9] Liu Y, Li Y, Wang YX, et al. Recent progress on vascular en-
考意义，对今后研究靶点的确认有一定的指导作 dothelial growth factor receptor inhibitors with dual targeting
用，同时为今后研发高效低毒的抗肿瘤药物打下良 capabilities for tumor therapy[J]. J Hematol Oncol, 2022, 15(1):
好基础。 89.
[10] Tian MM, Chen K, Huang JH, et al. Asiatic acid inhibits angio-
genesis and vascular permeability through the VEGF/VEGFR2
signaling pathway to inhibit the growth and metastasis of breast
References
cancer in mice[J]. Phytother Res, 2021, 35(11): 6389-6400.
[1] Chassaud LF, Fry BJ, Hawkins DR, et al. The metabolism of
[11] Meng YQ, Zhang LF, Liu DY, et al. Synthesis and antitumor
Asiatic acid, -madecassic acid and asiaticoside in the rat[J].
activity evaluation of novel ursolic acid derivatives[J]. J Asian
Arzneimittelforschung, 1971, 21(9): 1379-1384.
Nat Prod Res, 2016, 18(3): 280-288.
[2] Chen YZ, Li ZD, Gao F, et al. Effects of combined Chinese
[12] Meng YQ, Zhang WC, Ning ZT, et al. Synthesis and anti-tu-
drugs and chemotherapy in treating advanced non-small cell
mor activity of novel asiatic acid A ring-cleavage derivatives in
lung cancer[J]. Chin J Integr Med, 2009, 15(6): 415-419.
vitro[J]. Chin J New Drugs(中国新药杂志), 2017, 26(10):
[3] Hsu YL, Kuo PL, Lin LT, et al. Asiatic acid, a triterpene, in- 1157-1162.
duces apoptosis and cell cycle arrest through activation of extra- [13] Meng YQ, Zhao YW, Kuai ZY, et al. Synthesis and antitumor
cellular signal-regulated kinase and p38 mitogen-activated pro- activity evaluation of novel oleanolic acid derivatives[J]. J
tein kinase pathways in human breast cancer cells[J]. J Pharma- Asian Nat Prod Res, 2017, 19(10): 1000-1010.
col Exp Ther, 2005, 313(1): 333-344. [14] Meng YQ, Xing W, Kuai ZY, et al. Synthesis and anti-tumor
[4] Wang H, Ye JP. Regulation of energy balance by inflammation: activities of ring A derived analogues of oleanolic acid[J]. Chin
common theme in physiology and pathology[J]. Rev Endocr J Org Chem, 2017, 37(6): 1417.
Metab Disord, 2015, 16(1): 47-54. [15] Huang RZ, Wang CY, Li JF, et al. Synthesis, antiproliferative
[5] Bai XS, Deng CR, Li YX, et al. Anti-nociceptive effect and and apoptosis-inducing effects of novel asiatic acid derivatives
mechanism of madecassic acid[J]. J China Pharm Univ(中国药 containing α-aminophosphonates[J]. RSC Adv, 2016, 6(67):
科大学学报), 2024, 55(2): 230-235. 62890-62906.
[6] Malekan M, Ali Ebrahimzadeh M. Vascular endothelial growth [16] Jing Y, Wang G, Ge Y, et al. Synthesis, anti-tumor and anti-an-
factor receptors [VEGFR] as target in breast cancer treatment: giogenic activity evaluations of asiatic acid amino acid deriva-
current status in preclinical and clinical studies and future direc- tives[J]. Molecules, 2015, 20(4): 7309-7324.