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第  56 卷第  4 期                廖梦归,等:ASO    的发展、递送与免疫疗法的机遇挑战                                 431

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                                  专家介绍]朱晨,博士,现任中国科学院杭州医学研究所生物治疗与组学中心王雅俊研究员组博
                                 [
                                 士后。具体研究内容聚焦于以下两个方面:(1)细胞膜表面的糖基化                     RNA  的示踪以及其生物学功
                                 能研究。(2)通过蛋白工程化与人工智能辅助的蛋白设计,开发核酸分子的精准生物合成方法。
                                 近五年,在    Journal of Integrative Plant Biology, Nature Communications  等期刊发表学术论文
                                 5  篇。






                                  专家介绍]王雅俊,研究员,博士生导师,中国科学院“百人计划”(2024)、浙江省“海外高层次人
                                 [
                                 才计划”青年项目(2023)资助。现任中国科学院杭州医学研究所生物治疗与组学中心研究员。致
                                 力于化学生物学与合成生物学交叉领域的研究,核心目标是系统探索核酸的化学与生物学特性,
                                 开发核酸分子的大规模、精准生物合成与修饰平台,并推动其在药物研发与生物技术中的应用。
                                 具体研究内容聚焦于以下三个方面:(1)核酸的基础化学生物学研究,涵盖细胞膜表面的糖基化
                                 RNA,含有非天然碱基和糖环结构的功能性核酸、小核酸、mRNA                    等;(2)通过蛋白工程化与人工
                                 智能辅助的蛋白设计与进化,开发核酸分子的大规模、精准生物合成与修饰方法,(3)开发基于
                                 DNA、RNA   与  XNA  等多种核酸的功能分子、分子工具与治疗药物,为细胞命运与生物体系调控
                                 及疾病诊断和治疗提供新的策略。近五年,以第一作者和通信作者(含共同)于                         Nature Chemistry,
                                 Advanced  Materials,  Journal  of  the  American  Chemical  Society,  Nature  Communications,
                                 Nucleic Acids Research, Chemical Science  等期刊发表研究论文。
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