Page 27 - 《中国医疗器械杂志》2025年第2期

Chinese Journal of Medical Instrumentation 2025 年 第49卷 第2期

研 究 与 论 著

文章编号：1671-7104(2025)02-0141-07

基于SCT的健康颈髓形态学参数定量研究

【作 者】 金玮，刘浩，姜瑞瑶，刘广奇
上海市第六人民医院，上海市，200233
【摘 要】 目的 使用脊髓分析平台（Spinal Cord Toolbox, SCT）测定健康颈髓的形态学参数并研究性别、年龄和节段
对这些参数的影响。方法 采用回顾性研究方法，收集184名健康被试的颈髓磁共振图像并计算其形态学参
数，研究性别、年龄、节段对横截面积（cross-sectional area, CSA）与离心率的影响，对不同颈髓节段的
横截面积、前后径（antero-posterior diameter, AP）及左右径（right-left diameter, RL）进行相关性分析。
结果 男性的颈髓横截面积在C2~C7节段均显著大于女性（P＜0.05）。在C2~C6节段，青年组与中年组横
截面积的差别无统计学意义且均显著大于老年组。C4节段的横截面积最大，C7节段的横截面积最小，
C4和C5节段的离心率显著大于其他节段（P＜0.05）。在C2~C7节段，CSA与AP、RL均存在线性关系。
结论 该研究对今后通过归一化方法减少个体间差异，利用上述形态学参数作为生物标志物研究颈髓病变具
有重要意义。
【关 键 词】 颈髓；磁共振成像；形态学参数；脊髓分析平台
【中图分类号】 R318
【文献标志码】 A doi: 10.12455/j.issn.1671-7104.240337
Quantitative Study on Morphological Parameters of Healthy
Cervical Spinal Cord Based on SCT

【 Authors 】 JIN Wei, LIU Hao, JIANG Ruiyao, LIU Guangqi
Shanghai Sixth People’s Hospital, Shanghai, 200233
【 Abstract 】 Objective To utilize Spinal Cord Toolbox (SCT) to measure the morphological parameters of healthy
cervical spinal cords and explore the impact of gender, age and vertebral levels on them. Methods A
retrospective study was conducted, collecting cervical spinal cord magnetic resonance images of 184
healthy adults. Then, cross-sectional area (CSA), eccentricity, antero-posterior diameter (AP) and right-
left diameter (RL) were each computed for every subject. Then, impacts of gender, age and vertebral
level on CSA and eccentricity were explored. Moreover, linear correlation analysis was conducted among
CSA, AP and RL. Results The CSA of the cervical spinal cord in males was significantly larger than that
in females at C2~C7 segments (P＜0.05) . For C2~C6 segments, there was no statistically significant
difference in CSA between the young and middle-aged groups, but both were significantly larger than that
of the elderly group. CSA of C4 was the largest whereas CSA of C7 was the smallest. Eccentricity values
of C4 and C5 were significantly larger than those of other vertebral levels (P＜0.05). Linear correlation
was established between CSA, AP and RL at C2~C7 segments. Conclusion The results allow for
minimizing inter-subject variability using normalization, and thereby highlighting the importance of
morphological parameters as biomarkers in the research of cervical spinal lesions.
【Key words】 cervical spinal cord, magnetic resonance imaging (MRI), morphological parameters, Spinal Cord Toolbox
(SCT)

0 引言 髓相连，下端接T1胸椎段。它不仅负责传递大脑
发出的指令，使身体各部分能够协调地运动，而且
颈髓是脊髓的一部分，位于狭窄的椎管内，周
负责将身体的感觉信息反馈给大脑，使我们能够感
围被脑脊液所包围。颈髓共有8个节段，上端与延
知外界环境。因此，颈髓的健康直接关系到我们的
收稿日期：2024-06-21 运动、感觉和生命活动。颈髓的形态学参数在医学
作者简介：金玮，E-mail: 18930172425@189.cn
通信作者：刘广奇，E-mail: 162120589@qq.com 研究和临床诊断中具有重要的作用，了解颈髓的

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