Page 98 - 《中国药科大学学报》2026年第2期

学报
224 Journal of China Pharmaceutical University 2026, 57(2): 224 − 232

靶向毛囊的 3 种相对分子质量铁皮石斛多糖脂质体治疗

雄激素性脱发的效应研究

夏 丽 ，赵思洁 ，胡 洋 ，万亚菲 1*
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（ 南京中医药大学连云港附属医院, 连云港 222004； 中国药科大学药学院, 南京 210009）
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摘 要 基于铁皮石斛多糖（dendrobium officinale polysaccharides, DOP）促进毛发生长作用的前期研究基础，本研究旨在
通过相对分子质量和纳米载体调控 DOP 的皮肤角质渗透与毛囊靶向能力，以提升其对雄激素性脱发（androgenetic alopecia,
AGA）的治疗效果。采用甘露聚糖酶解法制备高（DOP）、中（MDOP）、低（LDOP）3 种相对分子质量多糖，并构建了相应
的脂质体（DOP-lip/MDOP-lip/LDOP-lip）。研究表明，DOP 脂质体能够有效实现毛囊靶向递送，并可借助小窝蛋白介导的
途径促进人真皮乳头细胞对其高效摄取。在睾酮诱导的 AGA 小鼠模型中，LDOP-lip 展现出良好的治疗效果，使毛囊数量与
形态基本恢复至正常水平。综上所述，DOP 脂质体通过精准递送与高效细胞摄取，在促进毛囊修复方面展现出新的应用潜力。
关键词 铁皮石斛多糖；雄激素性脱发；脂质体；毛囊靶向；毛乳头细胞
中图分类号 R944 文献标志码 A 文章编号 1000−5048(2026)02−0224−09
doi：10.11665/j.issn.1000−5048.2025091401

引用本文 夏丽，赵思洁，胡洋，等. 靶向毛囊的 3 种相对分子质量铁皮石斛多糖脂质体治疗雄激素性脱发的效应研究 [J]. 中国药科大学学
报，2026，57（2）：224-232.

Cite this article as: XIA Li, ZHAO Sijie, HU Yang, et al. Effects of polysaccharide liposomes of dendrobium officinale targeting hair follicles
in the treatment of androgenetic alopecia[J]. J China Pharm Univ, 2026, 57(2): 224-232.

Effects of polysaccharide liposomes of dendrobium officinale targeting hair
follicles in the treatment of androgenetic alopecia
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XIA Li , ZHAO Sijie , HU Yang , WAN Yafei 1*
1
Nanjing University of Chinese Medicine Lianyungang Affiliated Hospital, Lianyungang 222004;
2
School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Abstract Based on previous research on the promoting effect of dendrobium officinale polysaccharides (DOP)
on hair growth, this study aimed to regulate the skin keratin penetration and hair follicle targeting ability of DOP
through molecular weight and nano-carriers to enhance its therapeutic effect on androgenetic alopecia (AGA).
Three molecular weight polysaccharides, namely high (DOP), medium (MDOP), and low (LDOP), were prepared
by mannanase hydrolysis, and the corresponding liposomes (DOP-lip/MDOP-lip/LDOP-lip) were constructed.
Studies have shown that DOP liposomes can effectively achieve follicular targeted delivery and promote efficient
uptake by human dermal papilla cells through caveolin-mediated pathways. In the testosterone-induced AGA
mouse model, LDOP-lip demonstrated excellent therapeutic effects, restoring the number and morphology of hair
follicles to nearly normal levels. In summary, DOP liposomes show significant potential for promoting hair
follicle repair through precise delivery and efficient cellular uptake.
Key words dendrobium officinale polysaccharides; androgenic alopecia; liposomes; hair follicle
targeting; human dermal papilla cells

收稿日期 2025-09-14 * 通信作者 E-mail：1955389@qq.com