Page 63 - 《中国药科大学学报》2026年第2期

学报
Journal of China Pharmaceutical University 2026, 57(2): 189 − 195 189

·论 文·

甘青乌头正丁醇部位苷类化学成分研究

赵梦媛 ，方泗杨 ，李丹婷 ，李啟恩 ，潘 珂 ，殷志琦 1**
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（ 中国药科大学中药学院, 南京 211198； 青海大学藏医药研究中心, 西宁 810016）
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摘 要 对藏药甘青乌头 [Aconitum tanguticum (Maxim.) Stapf] 的苷类化学成分进行研究。采用硅胶、ODS、Sephadex LH-
20 柱色谱、半制备高效液相色谱等色谱技术，从甘青乌头乙醇提取物的正丁醇萃取部位中分离得到 8 个糖苷类化合物，根据
它们的理化性质与波谱数据分别鉴定为 N-4-O-(β-D-吡喃葡萄糖基)-苯乙基苯甲酰胺 (1)、N-(2'-β-D-吡喃葡萄糖基-5'-甲氧基
水杨基)-4-羟基-3-甲氧基邻氨基苯甲酸甲酯 (2)、N-(2'-β-D-吡喃葡萄糖基-5'-羟基水杨基)-4-羟基-3-甲氧基邻氨基苯甲酸甲酯
(3)、红景天苷 (4)、苄醇-β-樱草糖苷 (5)、苯乙醇-β-D-木糖-(1''→6')-β-D-吡喃葡萄糖苷 (6)、4-羟基苯乙氧基-8-O-β-D-[6-O-(4-O-
β-D-吡喃葡萄糖基)-阿魏酰基 ]-吡喃葡萄糖苷 (7)、苯乙醇-α-L-阿拉伯糖-(1''→6')-葡萄糖苷 (8)。其中，化合物 1 和 2 为新化合
物，化合物 5、6、8 为首次从甘青乌头中分离得到。
关键词 甘青乌头；化学成分；苷类化合物；分离鉴定
中图分类号 R29 文献标志码 A 文章编号 1000−5048(2026)02−0189−07
doi：10.11665/j.issn.1000−5048.2026012803

引用本文 赵梦媛，方泗杨，李丹婷，等. 甘青乌头正丁醇部位苷类化学成分研究 [J]. 中国药科大学学报，2026，57（2）：189-195.

Cite this article as: ZHAO Mengyuan, FANG Siyang, LI Danting, et al. Studies on glycosides from the n-butanol fraction of Aconitum
tanguticum[J]. J China Pharm Univ, 2026, 57(2): 189-195.

Studies on glycosides from the n-butanol fraction of Aconitum tanguticum
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ZHAO Mengyuan , FANG Siyang , LI Danting , LI Qien , PAN Ke , YIN Zhiqi 1**
1 School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198;
2 Tibetan Medicine Research Center of Qinghai University, Xining 810016, China
Abstract In order to investigate the chemical constituents of glycosides in Aconitum tanguticum (Maxim.)
Stapf, column chromatographic techniques such as silica gel, ODS, Sephadex LH-20, and semi-preparative high
performance liquid chromatography were used to afford eight glycosides from the n-butanol fraction of the 85%
ethanol extract of Aconitum tanguticum. Based on the physicochemical properties and spectral data, these
compounds were identified as N-4-O-(β-D-glucopyranosyl)-phenethylbenzamide (1), N-(2'-β-D-glucopyranosyl-
5'-methoxysalicyl)-4-hydroxy-3-methoxyanthranilic acid methyl ester (2), N-(2'-β-D-glucopyranosyl-5'-
hydroxysalicyl)-4-hydroxy-3-methoxyanthranilic acid methyl ester (3), salidroside (4), benzyl primeveroside (5),
phenethanol-β-D-xylose-(1''→6')-β-D-glucopyranoside (6), 4-dihydroxyphenethoxy-8-O-β-D-[6-O-(4-O-β-D-
glucopyranosyl)-feruloyl]-glucopyranoside (7), phenethanol-α-L-arabinopyranosyl-(1''→6')-β-D-glucopyranoside
(8)。Among them, compounds 1 and 2 were new compounds, and compounds 5,6,8 were isolated from Aconitum
tanguticum for the first time.
Key words Aconitum tanguticum; chemical constituents; glycosides; isolation and identification

This study was supported by the National Natural Science Foundation of China (No. U24A20351) and the Qing Lan Project of
Jiangsu Higher Education Institutions and Science

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收稿日期 2026-01-28 通信作者 E-mail：kpan@cpu.edu.cn
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E-mail：chyzq2005@126.com
基金项目 国家自然科学基金项目 (No. U24A20351)；江苏高校“青蓝工程”项目