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第 3 期 林晓裕等: 河豚毒素的提取纯化及医学药理活性研究进展 411
59. Shi Y X, Lu J Y, Li Y K, et al. Research progress of
[23] Mehta A, Grover C, Gupta R. Purification of lipase from voltage-gated sodium channel Nav1.7 in chronic pain[J].
Aspergillus fumigatus using octyl sepharose column Chinese Journal of Neuroanatomy, 2024, 40(4): 502 −
chromatography and its characterization[J]. Journal of 506.
Basic Microbiology, 2018, 58(10): 857 − 866. [34] Campos-Ríos A, Rueda-Ruzafa L, Herrera-Pérez S, et al.
[24] Suo R E, Tanaka M, Oyama H, et al. Tetrodotoxins in Tetrodotoxin: a new strategy to treat visceral pain?[J].
the flatworm Planocera multitentaculata[J]. Toxicon, Toxins, 2021, 13(7): 496.
2022, 216: 169 − 173. [35] Kavoosi M, O’Reilly T E, Kavoosi M, et al. Safety, tol-
[25] 黄枝梅. 河豚毒素的提取和分离纯化工艺研究 [D]. 福 erability, pharmacokinetics, and concentration-QTc ana-
州:福建农林大学,2010. lysis of tetrodotoxin: a randomized, dose escalation study
Huang Z M. Studies on the extraction and purification in healthy adults[J]. Toxins, 2020, 12(8): 511.
process of tetrodotoxin[D]. Fuzhou: Fujian Agriculture [36] 吴文瑶. 河豚毒素在骨癌痛大鼠中的镇痛作用及机制
and Forestry University, 2010. 研究 [D]. 武汉:华中科技大学,2022.
[26] 孙博伦. 织纹螺中河豚毒素的提取、纯化与制备技术 Wu W Y. The analgesic role of tetrodotoxin in rats with
研究 [D]. 舟山:浙江海洋大学,2018. cancer-induced bone pain[D]. Wuhan: Huazhong Uni-
Sun B L. Studies on extraction, purification and prepara- versity of Science and Technology, 2022.
tion technology of tetrodotoxin in Nassarius[D]. Zhou- [37] Hong B H, He J L, Sun J P, et al. Analgesia effect of en-
shan: Zhejiang Ocean University, 2018. teric sustained-release tetrodotoxin pellets in the rat[J].
[27] 易瑞灶,谢全灵,洪碧红,等. 用于高纯药源单体的 Pharmaceutics, 2020, 12(1): 32.
河豚毒素的制备方法:101367821B[P]. 2012-01-04. [38] 洪一顺. 河豚毒素及联合舒芬太尼在大鼠急性术后疼
Yi R Z, Xie Q L, Hong B H, et al. Preparation method of 痛中的作用及机制研究 [D]. 武汉:华中科技大学,
tetrodotoxin for high purity medicine source monomer: 2021.
CN101367821B[P]. 2012-01-04. Hong Y S. The role and mechanism of tetrodotoxin or
[28] 储智勇,卢瑛,钱晓明. 一种河豚毒素的快速高效纯 combined with sufentanil in a rat model of acute post-
化方法:113219114A[P]. 2021-08-06. operative pain[D]. Wuhan: Huazhong University of Sci-
Chu Z Y, Lu Y, Qian X M. Rapid and efficient purifica- ence and Technology, 2021.
tion method of tetrodotoxin: 113219114A[P]. 2021-08- [39] González-Cano R, Tejada M Á, Artacho-Cordón A, et al.
06. Effects of tetrodotoxin in mouse models of visceral
[29] 董颖超,吕学泽,杨洁,等. 一种分离纯化河豚毒素 pain[J]. Marine Drugs, 2017, 15(6): 188.
标准物质的装置:210729828U[P]. 2020-06-12. [40] 陈永强. 河豚毒素利多卡因抗心律失常复方制剂的研
Dong Y C, Lü X Z, Yang J, et al. Device for separating 究 [D]. 厦门:国家海洋局第三海洋研究所,2016.
and purifying tetrodotoxin standard substance: 210729- Chen Y Q. Study of tetrodotoxin and lidocaine compo-
828U[P]. 2020-06-12. und preparation for anti-arrhythmia[D]. Xiamen: Third In-
[30] 邓兴朝,黄连生,陈欢,等. 一种河豚毒素提取纯化 stitute of Oceanography State Oceanic Administration,
方法:108586475A[P]. 2018-09-28. 2016.
Deng X Z, Huang L S, Chen H, et al. Tetrodotoxin ex- [41] Hong B H, He J L, Le Q Q, et al. Combination formula-
traction and purification method: 108586475A[P]. 2018- tion of tetrodotoxin and lidocaine as a potential therapy
09-28. for severe arrhythmias[J]. Marine Drugs, 2019, 17(12):
[31] Edinoff A N, Flanagan C J, Sinnathamby E S, et al. 685.
Treatment of acute pain in patients on naltrexone: a nar- [42] Holmuhamedov E L, Chakraborty P, Oberlin A, et al.
rative review[J]. Current Pain and Headache Reports, Aging-associated susceptibility to stress-induced ventri-
2023, 27(7): 183 − 192. cular arrhythmogenesis is attenuated by tetrodotoxin[J].
[32] Wilson M J A, MacArthur C, Hewitt C A, et al. Intraven- Biochemical and Biophysical Research Communications,
ous remifentanil patient-controlled analgesia versus in- 2022, 623: 44 − 50.
tramuscular pethidine for pain relief in labour (RES- [43] Mohammed F H, Khajah M A, Yang M, et al. Blockade
PITE): an open-label, multicentre, randomised control- of voltage-gated sodium channels inhibits invasion of en-
led trial[J]. The Lancet, 2018, 392(10148): 662 − 672. docrine-resistant breast cancer cells[J]. International
[33] 史云欣,卢俊宇,李永康,等. 电压门控钠通道 Nav1.7 Journal of Oncology, 2016, 48(1): 73 − 83.
在慢性痛中的研究进展 [J]. 神经解剖学杂志,2024, [44] 张杰. 电压门控钠离子通道 Nav1.5 促进口腔鳞状细胞
40(4) :502 − 506. 癌的增殖、迁移和侵袭 [D]. 合肥:安徽医科大学,

