Page 184 - 《水产学报》2026年第3期

3 期 张天华，等：饲料中添加不同水平纳米氧化铁对黄颡鱼幼鱼肌肉发育的影响及其机理 50 卷

铁的饲料饲喂能够促进肌肉组织中蛋白的积累， tissue iron concentration and serum antioxidant status[J].
增加肌纤维直径，并通过促进 MRFs 以及 slc7a11 Aquaculture, 2019, 504: 148-157.
的基因表达，抑制 nf-κb1 基因的 mRNA 和蛋白表 [ 8 ] Qin X, Zhang J, Wang B, et al. Ferritinophagy is involved in
达水平来推动肌肉的生长和发育。这表明添加适 the zinc oxide nanoparticles-induced ferroptosis of vascular
宜水平的纳米氧化铁能够对肌肉组织的健康和发 endothelial cells[J]. Autophagy, 2021, 17(12): 4266-4285.
育产生积极影响。本研究也揭示了纳米氧化铁通 [ 9 ] He S X, Li R, Peng Y M, et al. ACSL4 contributes to ferrop-
过 NF-κB1 转录因子经调控 myog 和 slc7a11 启动 tosis-mediated rhabdomyolysis in exertional heat stroke[J].
子的转录活性，影响肌肉发育的潜在机制，为纳 Journal of Cachexia, Sarcopenia and Muscle, 2022, 13(3): 1717-
米氧化铁在黄颡鱼饲料添加剂中的应用提供了理 1730.
论依据。 [10] Li S B, He Y P, Chen K X, et al. RSL3 drives ferroptosis
through NF-κB pathway activation and GPX4 depletion in Glio-
（作者声明本文无利益冲突） blastoma[J]. Oxidative Medicine and Cellular Longevity, 2021,
2021(1): 2915019.
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