Page 22 - 《中国药科大学学报》2026年第2期

148 学报 Journal of China Pharmaceutical University 2026, 57(2): 144 − 154 第 57 卷

A
O O O
PikC HO CH 3
PikC
R 1 O
O HO H OH
O O OH O
R 2 O
O O O
HO N HO N R O OCH 3
O O
cmmA, cmmI
O O
Methymycin: R 1 =OH, R 2 =H R=OH, Cinnamomyicn A
Neomethmycin: R 1 =H, R 2 =OH Pikromycin R=H, Cinnamomyicn B
Novamethymycin: R 1 =OH, R 2 =OH
O
PimD O OleP
OH O
HO O 8 8a
O 5 4
HO O HO H OH O OH N
O OH F O HO
H 3 CO O O E CH 3 O O O O
A B C D OH O O
H 2 N O
O OH OH O GrhO3, GrhO7 O H O O OH
HO
Griseorhodin A Natamycin Oleandomycin
B C OH HO
20 COOH
PyrE2
AryC
HO NH 8 O H O H HN COOH
HO N N N N N O
O H O O H O O
OH Arylomycin A2
OH
O O O O H OH
O O O O
H 2 N
NH O
NH OH H
NH O N
Pyrroindomycins,PYRs O StaP
R=H,PYR-A O H
R R=Cl,PYR-B N N
OH 2 2'
O HN
OH OH O H O N StaP N
COOH TrpB StaN O
O H
H XiaM N C H NH NH O
N BorI COOH N NH 2
H O NH
HO
Xiamycin A Borrelidin Tryptorubin A Staurosporine
D H 3 CO
H 3 CO
O O O
HO O O
OH
H O
HN N H H N C 2 H 5
HO O N HN O O O O O N
O O HmtS HO HmtT OH H
N O O O O H 7 NO 2 OH
N O OH O N N O TxtE 4 N
H NH HmtT N O O 9a O O O
O N O AurH Ave E O 6 5
H H OH HO
N NH OCH 3
HO H Aureothin Avermectins A1a, AVM A1a Thaxtomin A
Himastatin
HN
O
H
O N O O NH 1 PntM
H StsuP450 NH S SgvP 2 COOH
N O H N O O
N 7' H N O NH HOOC
3 S
NH O
N CxnD O
H O N O
H OH OH
Griseoviridin Chuangxinmycin Pentalenolactone
DTDKP
图 4 链霉菌 P450 酶催化的反应类型