Page 105 - 《中国药科大学学报》2026年第2期

第 57 卷第 2 期 夏 丽，等：靶向毛囊的 3 种相对分子质量铁皮石斛多糖脂质体治疗雄激素性脱发的效应研究 231
A B ns C ns D ns

ns ns
***
**** ****
ns *** ***
4 000 150 0.8
Chloropromazine * ns
Mean fluourescence 2 000 Number of hair follicles Hair follicle length 0.4
M-β-CD 3 000 100 0.6
Amiloride 50
F-DOP-lip 1 000 0.2
0 0 0
Blank
Blank liposomes
Blank liposomes
Positive control
Positive control
M-β-CD
10 0 10 1 10 2 10 3 10 4 10 5 Blank F-DOP-lip Amiloride Chlorpromazine Blank control DOP-lip MDOP-lip LDOP-lip Blank control DOP-lip MDOP-lip LDOP-lip
E 0 d 7 d 14 d 21 d 24 d 28 d

Blank control

Positive control

Blank-lip

DOP-lip

MDOP-lip

LDOP-lip

Figure 4 Study on the intracellular mechanism and hair growth promotion effects of three molecular weight polysaccharide liposomes
( x ± s, n=3)
A-B: Mechanism of liposome endocytosis; C: Number of hair follicles; D: Hair follicle length; E: Evaluation of hair growth in mice and observation of
skin tissue slices
*P<0.05, ***P<0.001, ****P<0.000 1