Page 84 - 《中国药科大学学报》2025年第5期

616 学报 Journal of China Pharmaceutical University 2025, 56(5): 613 − 623 第 56 卷

Figure 1 Total ion chromatogram of Carum carvi L. extract
A:Negative ion mode；B:Positive ion mode

Figure 2 Total ion chromatogram of Carum carvi L. extract in blood
A: Blank control；B: Negative ion mode；C: Positive ion mode

Table 1 Chromatographic and MS information of blood components of Carum carvi L. extract by UPLC-Q-Exactive-orbitrap-HRMS
−6
No. t R /min Formula Adduct Measured(m/z) Error (×10 ) Fragment Compound
1 2.62 C 8 H 8 O 4 [M−H] − 167.021 1 −5.1 124,96 Vanillic acid
2 4.81 C 10 H 14 O 3 N 2 [M−H] − 209.092 2 −2.1 74,94,118,120,136, L-Kynurenine
146,174,192,209
3 13.07 C 8 H 8 NO 6 [M−H] − 212.002 4 −6.7 132,120,80 4-Hydroxy-3-methoxy-5-nitrobenzoic
acid
4 15.35 C 12 H 14 O 2 N 2 [M−H] − 217.097 4 −1.5 144,217 2,3,4,9-Tetrahydro-1H-β-carboline-3-
carboxylic acid
5 15.57 C 10 H 17 O [M−H] − 153.127 5 −3.1 93,95,107,135,153 α-Pinene-2-oxide
6 16.48 C 10 H 9 O 4 [M−H] − 193.049 9 −1.1 134,149,178,193 Ferulic acid
7 16.49 C 10 H 10 O 7 S [M−H] − 273.007 4 3.7 134,149,178,193 Ferulic acid-4-O-sulfate
8 17.49 C 16 H 24 O 9 [M−H] − 359.134 7 0.6 71,85,113,160 Deoxyloganic acid