Page 13 - 《中国药科大学学报》2025年第5期
P. 13

第  56 卷第  5 期                涂远博,等:肝脏器官芯片在成药性评价中的应用进展                                      545

               [2]   Van Norman GA. Limitations of animal studies for predicting  chip:  the  convergence  of  microphysiological  systems  and
                    toxicity in  clinical  trials:  is  it  time  to  rethink  our  current   ap-  organoids[J]. Front Cell Dev Biol, 2022, 10: 1043117.
                    proach[J]? JACC Basic Transl Sci, 2019, 4(7): 845-854.  [17]   Calamaio S, Serzanti M, Boniotti J, et al. Human iPSC-derived
               [3]   Farzaneh  Z,  Khojastehpour  F,  Keivan  M,  et  al.  Co-culture  of  3D  hepatic  organoids  in  a  miniaturized  dynamic  culture
                    liver  parenchymal  cells  with  non-parenchymal  cells  under  2D  system[J]. Biomedicines, 2023, 11(8): 2114.
                    and 3D culture systems; A review[J]. Curr Stem Cell Res Ther,  [18]   Kogler S, Pedersen GM, Martínez-Ramírez F, et al. An FDA-
                    2023, 18(7): 904-916.                            validated, self-cleaning liquid chromatography-mass spectrome-
               [4]   Moradi  E,  Jalili-Firoozinezhad  S,  Solati-Hashjin  M.  Microflu-  try  system  for  determining  small-molecule drugs  and   metabo-
                    idic organ-on-a-chip models of human liver tissue[J]. Acta Bio-  lites  in  organoid/organ-on-chip  medium[J].  Anal  Chem,  2024,
                    mater, 2020, 116: 67-83.                         96(29): 12129-12138.
               [5]   Fabre  K,  Berridge  B,  Proctor  WR,  et  al.  Introduction  to  a  [19]   Zhao Y, Kankala RK, Wang SB, et al. Multi-organs-on-chips:
                    manuscript series on the characterization and use of microphysi-  towards  long-term  biomedical  investigations[J].  Molecules,
                    ological  systems  (MPS)  in  pharmaceutical  safety  and  ADME  2019, 24(4): 675.
                    applications[J]. Lab Chip, 2020, 20(6): 1049-1057.  [20]   Asif A, Park SH, Manzoor Soomro A, et al. Microphysiologi-
               [6]   Rumsey  JW,  Lorance  C,  Jackson  M,  et  al.  Classical  comple-  cal system with continuous analysis of albumin for hepatotoxic-
                    ment pathway inhibition in a “human-on-A-chip” model of au-  ity modeling and drug screening[J]. J Ind Eng Chem, 2021, 98:
                    toimmune demyelinating neuropathies[J]. Adv Ther, 2022, 5(6):  318-326.
                    2200030.                                    [21]   Du  K,  Li  SB,  Li  CP,  et  al.  Modeling  nonalcoholic  fatty  liver
               [7]   National  Medical  Products  Administration  Center  for  Drug  disease on a liver lobule chip with dual blood supply[J]. Acta
                    Evaluation. Notice of the Center for Drug Evaluation of the Na-  Biomater, 2021, 134: 228-239.
                    tional  Medical  Products  Administration  on  the  Release  of  the  [22]   Kostrzewski T, Snow S, Battle AL, et al. Modelling human liv-
                    “Technical Guidelines for Non-Clinical Research and Evalua-  er fibrosis in the context of non-alcoholic steatohepatitis using a
                    tion of Gene Therapy Products (Trial)” and “Technical Guide-  microphysiological system[J]. Commun Biol, 2021, 4(1): 1080.
                    lines  for  Non-Clinical  Research  of  Genetically  Modified  Cell  [23]   Freag  MS,  Namgung  B,  Reyna  Fernandez  ME,  et  al.  Human
                    Therapy  Products  (Trial)”  (No.  49[2021])[EB/OL].  (2021-11-  nonalcoholic  steatohepatitis  on  a  chip[J].  Hepatol  Commun,
                    30)[2024-10-04].  https://www.cde.org.cn/main/news/viewInfo-  2020, 5(2): 217-233.
                    Common/41bc557bec23a6ebfb0e148cc989f041.    [24]   Lee J, Choi B, No DY, et al. A 3D alcoholic liver disease mod-
               [8]   Wu  QR,  Liu  JF,  Wang  XH,  et  al.  Organ-on-a-chip:  recent  el on a chip[J]. Integr Biol (Camb), 2016, 8(3): 302-308.
                    breakthroughs  and  future  prospects[J].  Biomed  Eng  Online,  [25]   Nawroth JC, Petropolis DB, Manatakis DV, et al. Modeling al-
                    2020, 19(1): 9.                                  cohol-associated  liver  disease  in  a  human  Liver-Chip[J].  Cell
               [9]   Tajeddin  A,  Mustafaoglu  N.  Design  and  fabrication  of  organ-  Rep, 2021, 36(3): 109393.
                    on-chips:  promises  and  challenges[J].  Micromachines  (Basel),  [26]   Liu M, Yan Q, Sun Y, et al. A hepatocyte differentiation model
                    2021, 12(12): 1443.                              reveals  two  subtypes  of  liver  cancer  with  different  oncofetal
               [10]   Pisapia  F,  Balachandran  W,  Rasekh  M.  Organ-on-a-chip:  de-  properties and therapeutic targets[J]. Proc Natl Acad Sci USA,
                    sign and simulation of various microfluidic channel geometries  2020, 117(11): 6103-6113.
                    for the influence of fluid dynamic parameters[J]. Appl Sci, 2022,  [27]   Zou ZY, Lin Z, Wu CL, et al. Micro-engineered organoid-on-a-
                    12(8): 3829.                                     chip based  on  mesenchymal  stromal  cells  to  predict   im-
               [11]   Liu S, Cheng CL, Zhu LY, et al. Liver organoids: updates on  munotherapy  responses  of  HCC  patients[J].  Adv  Sci  (Weinh),
                    generation strategies and biomedical applications[J]. Stem Cell  2023, 10(27): e2302640.
                    Res Ther, 2024, 15(1): 244.                 [28]   Yang ZH, Zhou ZH, Si TX, et al. High throughput confined mi-
               [12]   Scheidecker B, Poulain S, Sugimoto M, et al. Dynamic, IPSC-  gration microfluidic device for drug screening[J]. Small, 2023,
                    derived  hepatic  tissue  tri-culture  system  for  the  evaluation  of  19(16): e2207194.
                    liver  physiology  in  vitro[J].  Biofabrication,  2024,  16(2).  [29]   Sharifi  F,  Yesil-Celiktas  O,  Kazan  A,  et  al.  A  hepatocellular
                    doi:10.1088/1758-5090/ad30c5.                    carcinoma–bone  metastasis-on-a-chip model  for  studying   thy-
               [13]   Odanga JJ, Anderson SM, Breathwaite EK, et al. Characteriza-  moquinone-loaded anticancer nanoparticles[J]. Bio Des Manuf,
                    tion  of  diseased  primary  human  hepatocytes  in  an  all-human  2020, 3(3): 189-202.
                    cell-based triculture system[J]. Sci Rep, 2024, 14(1): 6772.  [30]   Sun W, Chen YQ, Wang MF, et al. Study on drug resistance to
               [14]   Zhao ZX, Chen XY, Dowbaj AM, et al. Organoids[J]. Nat Rev  tumor  cell  in  oxygen  gradient  and  co-culture  microfluidic
                    Meth Primers, 2022, 2: 94.                       chip[J]. Chin J Anal Chem, 2020, 48(2): 180-186.
               [15]   Li  Y,  Xu  C,  Zhou  XT,  et  al.  DNA  adductomics  aided  rapid  [31]   Lim J, Choi H, Ahn J, et al. 3D high-content culturing and drug
                    screening of genotoxic impurities using nucleosides and 3D bio-  screening platform to study vascularized hepatocellular carcino-
                    printed human liver organoids[J]. Talanta, 2024, 273: 125902.  ma in hypoxic condition[J]. Adv NanoBiomed Res, 2021, 1(12):
               [16]   Baptista LS, Porrini C, Kronemberger GS, et al. 3D organ-on-a-  2100078.
   8   9   10   11   12   13   14   15   16   17   18