Page 111 - 《中国药科大学学报》2025年第4期
P. 111
学报
Journal of China Pharmaceutical University 2025, 56(4): 507 − 514 507
·综 述·
中药活性成分调节脂质代谢改善代谢功能障碍
相关脂肪性肝病的研究进展
李海岚，朱紫含，李 月，肖梦雪，张媛媛，寇俊萍 *
（中国药科大学中药学院中药药理与中医药学系, 南京 211198）
摘 要 代谢功能障碍相关脂肪性肝病（metabolic dysfunction-associated steatotic liver disease，MASLD）是最常见的慢性肝
病，其全球发病率高，影响超过 30% 的人口，病程漫长，且严重危害人类生命健康。脂质代谢在 MASLD 的发生发展中发挥
着重要作用，越来越多的研究表明中药活性成分可以调节脂质代谢以改善 MASLD，由于其具有多靶点调控且副作用较少的
优势，显示出巨大的应用潜力和价值。MASLD 病理机制复杂，中药活性成分可从多方面改善疾病，目前在脂质代谢方面缺乏
系统论述。因此，聚焦脂质代谢，从调节脂质摄取、脂质合成、脂质氧化、脂质分泌等方面综述中药活性成分改善 MASLD 的
最新研究进展，以期为中药活性成分调节脂质代谢改善 MASLD 提供更多理论参考。
关键词 中药活性成分；脂质代谢；代谢功能障碍相关脂肪性肝病
中图分类号 R284 文献标志码 A 文章编号 1000−5048(2025)04−0507−08
doi：10.11665/j.issn.1000−5048.2024043001
引用本文 李海岚，朱紫含，李月，等. 中药活性成分调节脂质代谢改善代谢功能障碍相关脂肪性肝病的研究进展 [J]. 中国药科大学学报，
2025，56（4）：507 − 514.
Cite this article as: LI Hailan, ZHU Zihan, LI Yue, et al. Research progress on active ingredients of traditional Chinese medicine improving
metabolic dysfunction-associated steatotic liver disease via regulating lipid metabolism[J]. J China Pharm Univ, 2025, 56(4): 507 − 514.
Research progress on active ingredients of traditional Chinese medicine
improving metabolic dysfunction-associated steatotic liver disease via
regulating lipid metabolism
LI Hailan, ZHU Zihan, LI Yue, XIAO Mengxue, ZHANG Yuanyuan, KOU Junping *
Department of Pharmacology of Chinese Material Medical, School of Traditional Chinese Pharmacy, China Pharmaceutical
University, Nanjing 211198, China
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver
disease with high global prevalence and long course, which affects more than 30% of the population and seriously
endangers human health. Lipid metabolism plays an important role in the occurrence and development of
MASLD. An increasing number of studies have shown that active ingredients in traditional Chinese medicine can
regulate lipid metabolism to improve MASLD. Due to the obvious advantages of multi-target regulation and
fewer side effects, the active ingredients have shown great potential and value for application. However, the
pathological mechanism of MASLD is intricate and the active ingredients of traditional Chinese medicine can
improve MASLD from multiple aspects, there is currently a lack of systematic discussion on lipid metabolism.
Therefore, this review focuses on lipid metabolism and reviews the latest research progress of active ingredients
from traditional Chinese medicine in ameliorating MASLD from the aspects of lipid uptake, lipid synthesis, lipid
oxidation, lipid secretion, etc., in order to provide more theoretical references for active ingredients of traditional
Chinese medicine in regulating lipid metabolism to improve MASLD.
收稿日期 2024-04-30 * 通信作者 Tel：025-86185158 E-mail：junpingkou@163.com
基金项目 科技部重大新药创制专项（No. 2017ZX09301050）
