Page 95 - 《运动与健康科学》(英文)2024年第2期

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TaggedAPTARAEndPA and mortality in type 2 diabetes 217
Table 2
TaggedAPTARACaptionLeisure-time physical activity and all-cause mortality and cardiovascular disease. TaggedAPTARAEnd
No leisure-time Leisure-time PA Leisure-time PA Leisure-time PA
PATaggedAPTARAEnd below recommendationTaggedAPTARAEnd at recommendationTaggedAPTARAEnd above recommendationTaggedAPTARAEndTaggedAPTARAEndTaggedAPTARAEndTaggedAPTARATbody
All-cause mortalityTaggedAPTARAEndTaggedAPTARAEnd
UK Biobank (n = 14,913; deaths = 1571)TaggedAPTARAEnd 1391/162TaggedAPTARAEnd 5775/610TaggedAPTARAEnd 2956/306TaggedAPTARAEnd 4791/493TaggedAPTARAEndTaggedAPTARAEnd
Crude incidence rate/1000 person-yearsTaggedAPTARAEnd 12.8 (10.914.9)TaggedAPTARAEnd 11.5 (10.612.5)TaggedAPTARAEnd 11.3 (10.112.7)TaggedAPTARAEnd 11.3 (10.312.3)TaggedAPTARAEndTaggedAPTARAEnd
Model 1 (HR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 0.80 (0.670.95)TaggedAPTARAEnd 0.73 (0.600.88)TaggedAPTARAEnd 0.65 (0.550.78)TaggedAPTARAEndTaggedAPTARAEnd
Model 2 (HR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 0.90 (0.751.04)TaggedAPTARAEnd 0.84 (0.691.02)TaggedAPTARAEnd 0.78 (0.650.94)TaggedAPTARAEndTaggedAPTARAEnd
Model 3 (HR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 0.94 (0.791.12)TaggedAPTARAEnd 0.90 (0.741.10)TaggedAPTARAEnd 0.85 (0.701.02)TaggedAPTARAEndTaggedAPTARAEnd
Model 4 (HR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 0.96 (0.801.14)TaggedAPTARAEnd 0.93 (0.771.13)TaggedAPTARAEnd 0.87 (0.721.05)TaggedAPTARAEndTaggedAPTARAEnd
China Kadoorie Biobank (n = 17,457; deaths = 2357)TaggedAPTARAEnd 9523/1232TaggedAPTARAEnd 616/74TaggedAPTARAEnd 1186/169TaggedAPTARAEnd 6132/882TaggedAPTARAEndTaggedAPTARAEnd
Crude incidence rate/1000 person-yearsTaggedAPTARAEnd 19.2 (18.220.3)TaggedAPTARAEnd 18.5 (14.723.2)TaggedAPTARAEnd 21.6 (18.625.1)TaggedAPTARAEnd 21.5 (20.123.0)TaggedAPTARAEndTaggedAPTARAEnd
Model 1 (HR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 0.86 (0.681.09)TaggedAPTARAEnd 0.82 (0.700.96)TaggedAPTARAEnd 0.69 (0.630.75)TaggedAPTARAEndTaggedAPTARAEnd
Model 2 (HR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 0.87 (0.681.10)TaggedAPTARAEnd 0.88 (0.751.03)TaggedAPTARAEnd 0.77 (0.700.85)TaggedAPTARAEndTaggedAPTARAEnd
Model 3 (HR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 0.87 (0.681.10)TaggedAPTARAEnd 0.88 (0.741.03)TaggedAPTARAEnd 0.77 (0.700.85)TaggedAPTARAEndTaggedAPTARAEnd
Model 4 (HR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 0.86 (0.681.09)TaggedAPTARAEnd 0.88 (0.751.03)TaggedAPTARAEnd 0.77 (0.700.85)TaggedAPTARAEndTaggedAPTARAEnd
Cardiovascular mortalityTaggedAPTARAEndTaggedAPTARAEnd
UK Biobank (n = 14,913; deaths = 392)TaggedAPTARAEnd 1391/50TaggedAPTARAEnd 5775/154TaggedAPTARAEnd 2956/73TaggedAPTARAEnd 4791/115TaggedAPTARAEndTaggedAPTARAEnd
Crude incidence rate/1000 person-yearsTaggedAPTARAEnd 3.9 (3.05.2)TaggedAPTARAEnd 2.9 (2.53.4)TaggedAPTARAEnd 2.7 (2.13.4)TaggedAPTARAEnd 2.6 (2.23.2)TaggedAPTARAEndTaggedAPTARAEnd
Model 1 (sHR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 0.67 (0.490.92)TaggedAPTARAEnd 0.58 (0.400.83)TaggedAPTARAEnd 0.51 (0.360.71)TaggedAPTARAEndTaggedAPTARAEnd
Model 2 (sHR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 0.75 (0.551.04)TaggedAPTARAEnd 0.68 (0.470.98)TaggedAPTARAEnd 0.61 (0.430.86)TaggedAPTARAEndTaggedAPTARAEnd
Model 3 (sHR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 0.80 (0.581.11)TaggedAPTARAEnd 0.75 (0.521.09)TaggedAPTARAEnd 0.69 (0.480.97)TaggedAPTARAEndTaggedAPTARAEnd
Model 4 (sHR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 0.83 (0.601.15)TaggedAPTARAEnd 0.79 (0.541.15)TaggedAPTARAEnd 0.72 (0.511.03)TaggedAPTARAEndTaggedAPTARAEnd
China Kadoorie Biobank (n = 17,457; deaths = 1060)TaggedAPTARAEnd 9523/547TaggedAPTARAEnd 616/39TaggedAPTARAEnd 1186/83TaggedAPTARAEnd 6132/391TaggedAPTARAEndTaggedAPTARAEnd
Crude incidence rate/1000 person-yearsTaggedAPTARAEnd 8.5 (7.89.3)TaggedAPTARAEnd 9.7 (7.113.3)TaggedAPTARAEnd 10.6 (8.513.1)TaggedAPTARAEnd 9.5 (8.610.5)TaggedAPTARAEndTaggedAPTARAEnd
Model 1 (sHR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 1.04 (0.751.45)TaggedAPTARAEnd 0.93 (0.741.17)TaggedAPTARAEnd 0.70 (0.610.80)TaggedAPTARAEndTaggedAPTARAEnd
Model 2 (sHR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 1.06 (0.761.48)TaggedAPTARAEnd 1.01 (0.801.28)TaggedAPTARAEnd 0.79 (0.690.92)TaggedAPTARAEndTaggedAPTARAEnd
Model 3 (sHR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 1.06 (0.761.47)TaggedAPTARAEnd 1.01 (0.801.28)TaggedAPTARAEnd 0.79 (0.690.92)TaggedAPTARAEndTaggedAPTARAEnd
Model 4 (sHR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 1.06 (0.761.48)TaggedAPTARAEnd 1.01 (0.801.28)TaggedAPTARAEnd 0.79 (0.680.91)TaggedAPTARAEndTaggedAPTARAEnd
Major adverse cardiovascular eventsTaggedAPTARAEndTaggedAPTARAEnd
UK Biobank (n = 14,320; events = 2345)TaggedAPTARAEnd 1322/221TaggedAPTARAEnd 5550/948TaggedAPTARAEnd 2857/443TaggedAPTARAEnd 4591/733TaggedAPTARAEndTaggedAPTARAEnd
Crude incidence rate/1000 person-yearsTaggedAPTARAEnd 20.1 (17.623.0)TaggedAPTARAEnd 20.6 (19.322.0)TaggedAPTARAEnd 18.6 (16.920.4)TaggedAPTARAEnd 19.1 (17.720.5)TaggedAPTARAEndTaggedAPTARAEnd
Model 1 (sHR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 0.96 (0.831.11)TaggedAPTARAEnd 0.83 (0.700.97)TaggedAPTARAEnd 0.79 (0.680.92)TaggedAPTARAEndTaggedAPTARAEnd
Model 2 (sHR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 1.02 (0.881.18)TaggedAPTARAEnd 0.90 (0.771.07)TaggedAPTARAEnd 0.87 (0.741.02)TaggedAPTARAEndTaggedAPTARAEnd
Model 3 (sHR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 1.07 (0.921.24)TaggedAPTARAEnd 0.97 (0.821.15)TaggedAPTARAEnd 0.94 (0.801.11)TaggedAPTARAEndTaggedAPTARAEnd
Model 4 (sHR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 1.10 (0.941.27)TaggedAPTARAEnd 1.00 (0.851.19)TaggedAPTARAEnd 0.98 (0.841.15)TaggedAPTARAEndTaggedAPTARAEnd
China Kadoorie Biobank (n = 16,127; events = 4458)TaggedAPTARAEnd 8931/2211TaggedAPTARAEnd 569/154TaggedAPTARAEnd 1076/303TaggedAPTARAEnd 5551/1790TaggedAPTARAEndTaggedAPTARAEnd
Crude incidence rate/1000 person-yearsTaggedAPTARAEnd 40.5 (38.942.6)TaggedAPTARAEnd 46.6 (39.854.6)TaggedAPTARAEnd 47.3 (42.353.0)TaggedAPTARAEnd 55.8 (53.258.4)TaggedAPTARAEndTaggedAPTARAEnd
Model 1 (sHR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 1.10 (0.901.30)TaggedAPTARAEnd 1.00 (0.891.13)TaggedAPTARAEnd 1.06 (1.001.13)TaggedAPTARAEndTaggedAPTARAEnd
Model 2 (sHR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 1.01 (0.861.19)TaggedAPTARAEnd 0.92 (0.821.04)TaggedAPTARAEnd 0.96 (0.891.03)TaggedAPTARAEndTaggedAPTARAEnd
Model 3 (sHR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 1.01 (0.861.19)TaggedAPTARAEnd 0.93 (0.821.05)TaggedAPTARAEnd 0.97 (0.901.04)TaggedAPTARAEndTaggedAPTARAEnd
Model 4 (sHR (95%CI))TaggedAPTARAEnd 1 (reference)TaggedAPTARAEnd 1.01 (0.861.19)TaggedAPTARAEnd 0.93 (0.821.05)TaggedAPTARAEnd 0.96 (0.891.03)TaggedAPTARAEndTaggedAPTARAEndTaggedAPTARAEnd
Notes: Categories of leisure-time PA deﬁned as: none (0 MET-h/week), below recommendation (>07.49 MET-h/week), at recommendation (7.514.9 MET-h/
week), and above recommendation (15 MET-h/week).TaggedAPTARAEnd
Model 1: adjusted for sex and age (timescale).TaggedAPTARAEnd
Model 2: Multivariable-adjusted.TaggedAPTARAEnd
UK Biobank: Model 1 + education (no qualiﬁcations, qualiﬁcations, not college/university degree, college/university degree), Townsend deprivation index (contin-
uous), living with partner (yes/no), ethnicity (European, South Asian, African Caribbean, other), employment (sedentary work, some standing and no heavy work,
heavy manual work, not in employment, retired), transportation (passive, walking, cycling, working from home), smoking (never, former, current), alcohol intake
(never, former, current <3 times/week, current >3 times/week), diet quality index (0, 1, 23), body mass index (continuous), family history of diabetes, cardiovas-
cular disease, or cancer (yes/no), inclusion method (self-reported type 2 diabetes/use of medication or biochemistry), depression (yes/no), loneliness (yes/no),
diabetes duration (continuous).TaggedAPTARAEnd
China Kadoorie Biobank: Model 1 + education (no school or primary school, middle school, high school or higher), household income (<RMB10,000/year,
RMB10,00019,999/year, RMB20,00034,999/year, RMB35,000/year), marital status (married, yes/no), has health coverage (yes/no), employment
(sedentary, standing, manual work, not in employment, retired), transportation (passive, walking, cycling, working from home), smoking (never, occasional,
former regular, current), alcohol intake (never/occasionally, former weekly, current <3 days/week, current 3 days/week), regular fruit consumption
(4 days/week, yes/no), regular meat consumption (4 days/week, yes/no), body mass index, (continuous), family history of diabetes, cardiovascular disease, or
cancer (yes/no), inclusion method (self-reported type 2 diabetes/use of medication or biochemistry), experienced food shortage with weight loss (yes/no), major
depression in last 12 months (yes/no), diabetes duration (continuous).TaggedAPTARAEnd
Model 3 (main model): Model 2 + adjustment for body mass index.TaggedAPTARAEnd
Model 4: Model 3 + adjustment for use of glucose-lowering drugs, statins, and blood-pressure-lowering drugs.TaggedAPTARAEnd
Abbreviations: 95%CI = 95% conﬁdence interval; HR = hazard ratio; MET = metabolic equivalent; PA = physical activity; sHR = subdistribution hazard ratio.TaggedAPTARAEnd

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