Page 96 - 《运动与健康科学》(英文)2024年第2期

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TaggedAPTARAEnd218 J. Tarp et al.

Fig. 1. Doseresponse associations between leisure-time PA and all-cause mortality and cardiovascular disease. Solid lines are HRs or subdistribution HRs (based
on Model 3) with 95%CI in shaded areas. Vertical shaded area is recommended level of PA. Knot locations are 2, 10, and 41 MET-h/week (UK Biobank) and 10,
23, and 53 MET-h/week (China Kadoorie Biobank). Doseresponse curves are truncated at 55 MET-h/week to maintain data overlap between the cohorts. p for
non-linearity (all-cause mortality) = 0.51 (UK Biobank) and 0.03 (China Kadoorie Biobank). p for non-linearity (cardiovascular mortality) = 0.69 (UK Biobank)
and 0.97 (China Kadoorie Biobank). p for non-linearity (major adverse cardiovascular events) = 0.77 (UK Biobank) and 0.61 (China Kadoorie Biobank).
TaggedAPTARAFigure 95%CI = 95% confidence interval; HR = hazard ratio; MET = metabolic equivalent; PA = physical activity; sHR = subdistribution hazard ratio.TaggedAPTARAEnd

Fig. 2. Leisure-time PA and all-cause mortality by participant characteristics. HRs (based on Model 3) with 95%CI. No LTPA: 0 MET-h/week; Below: belowrecom-
mendation (>07.49 MET-h/week); At: recommended levels (7.514.9 MET-h/week); Above: above recommendation (15 MET-h/week). p value for interaction
from likelihood ratio test. Interaction with age examined by setting time-on-study as the timescale, including an indicator for above vs. below sixty years old, and an
interaction term between the age-indicator and leisure-time PA. Estimates for participants with no history of CVD are from main analysis, included for comparison.
Numbers of participants (deaths) in UK Biobank are: women (5538 (439)), men (9375 (1132)), included from self-report (12,005 (1310)), included from biochemistry
(2908 (261)), <60 years of age (6617 (350)), 60 years of age (8296 (1221)), diabetes duration <5 years (9185 (820)), diabetes duration 5 years (5728 (751)), no
history of CVD (14,913 (1573)), and a history of CVD (2028 (445)). Numbers of participants (deaths) in China Kadoorie Biobank are: women (10,547 (1321)), men
(6910 (1036)), included from self-report (9227 (1420)), included from biochemistry (8230 (937)), <60 years of age (10,123 (658)), 60 years of age (7334 (1699)),
diabetes duration <5 years (13,037 (1562)), diabetes duration 5 years (4420 (795)), no history of CVD (17,457 (2357)), and a history of CVD (2952 (771)).
CVD = cardiovascular disease; HR = hazard ratio; LTPA = leisure-time physical activity; MET = metabolic equivalent; PA = physical activity.TaggedAPTARAEnd