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TaggedAPTARAEnd220                                                                              J. Tarp et al.
         while there were no named light intensity activities in the  critically revised the manuscript; MASL, KED, BdPC, MRL,
         questionnaire given to the Chinese cohort. Light intensity  RWT, UE, and DD conceived and designed the study, inter-
         physical activities likely also contribute to lower mortality  preted the results, and critically revised the manuscript. All
         risk 5,10  but are not included in current quantitative PA recom-  authors have read and approved the final version of the manu-
         mendations. We included light do-it-yourself activities  script, and agree with the order of presentation of the authors.TaggedAPTARAEnd
         because this was 1 of 5 named leisure activity categories. The
         median contribution, among those reporting any, was 2.1  TaggedAPTARAH1Competing interestsTaggedAPTARAEnd
         MET-h/week. (b) Self-reported PA is imprecisely measured.
                                                                  TaggedAPTARAPJT received funding from the Danish Diabetes Association
         When PA is assessed by devices, the magnitude of associations
                                                               during the conduct of the study; DD received funding from the
         with mortality outcomes tend to be much stronger, and the
                                                               Australian National Health and Medical Research Council and
         maximal risk reduction is observed at lower absolute levels of
         activity. 38,39  In addition, we accounted for non-leisure-time  the New South Wales Government; MASL was funded by
                                                               the Spanish Ministry of Universities under application
         PAs by adjustment based on categorical variables, which may
                                                               33.50.460A.752 and by the European Union NextGenera-
         leave residual bias. Large observational studies with device-mea-
                                                               tionEU/PRTR through a Margarita Salas contract of the
         sured total PA will provide more robust quantifications of the
                                                               University of Vigo; and BdPC is supported by the Government
         doseresponse relationship and the minimal amount of PA
                                                               of Andalusia, Research Talent Recruitment Programme
         needed to prevent major health outcomes in adults with type
                  40                                           (EMERGIA 2020/00158). The funding sources had no role in
         2 diabetes.  (c) There was no association between leisure-time
                                                               the design and conduct of the study; collection, management,
         PA and mortality in the subsample of UK Biobank participants
                                                               analysis, and interpretation of the data; preparation, review, or
         with repeated dietary recalls (n = 5857), which may indicate
                                                               approval of the manuscript; or decision to submit the manu-
         residual confounding from diet quality or quantity. However, this
                                                               script for publication. The other authors declare that they have
         subsample may also represent a highly selected and motivated
         group, which can lead to bias in observational studies of  no competing interests.TaggedAPTARAEnd
         aetiology. 41  Finally, as an observational study, residual
         confounding and other biases may also impact the observed  TaggedAPTARAH1Data availability statementTaggedAPTARAEnd
                                                                  TaggedAPTARAPThis manuscript was prepared based on data available to
         doseresponse relationships.TaggedAPTARAEnd
                                                               Bona Fide researchers. Application for UK Biobank data can
                                                               be made here: https://www.ukbiobank.ac.uk/enable-your-
         TaggedAPTARAH15. ConclusionTaggedAPTARAEnd
                                                               research/apply-for-access. Application for China Kadoorie
            TaggedAPTARAPThe PA recommendations given by the WHO and the
                                                               Biobank data can be made here: https://www.ckbiobank.org/
         American Diabetes Association are quantitatively identical to
         general population guidelines. 10  Our study provides little  data-access.TaggedAPTARAEnd
         empirical support for such universal guidelines and messaging,
         suggesting a tailored PA recommendation may be appropriate  TaggedAPTARAH1Supplementary materialsTaggedAPTARAEnd
         for adults with type 2 diabetes.TaggedAPTARAEnd          TaggedAPTARAPSupplementary materials associated with this article can be
            TaggedAPTARAPLeisure-time PA was inversely associated with all-cause
                                                               found in the online version at doi:10.1016/j.jshs.2023.10.004.TaggedAPTARAEnd
         and cardiovascular mortality in British and Chinese adults, but
         the magnitude of the associations was small and inconsistent
                                                               TaggedAPTARAH1ReferencesTaggedAPTARAEnd
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                                                                  diabetes mellitus and its complications. Nat Rev Endocrinol 2018;14:
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         for all-cause mortality in British adults while the opposite
                                                               TaggedAPTARAListItem TaggedAPTARAListLabel2TaggedAPTARAEnd. Gyldenkerne C, Knudsen JS, Olesen KKW, et al. Nationwide trends in
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                                                                  dc21-0383TaggedAPTARAEnd.
         vascular events in British adults but not in Chinese adults.TaggedAPTARAEnd
                                                               TaggedAPTARAListItem TaggedAPTARAListLabel3TaggedAPTARAEnd. Gregg EW. The changing tides of the type 2 diabetes epidemic-smooth
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         TaggedAPTARAH1AcknowledgmentsTaggedAPTARAEnd             Diabetes Care 2017;40:1289–97TaggedAPTARAEnd.
                                                               TaggedAPTARAListItem TaggedAPTARAListLabel4TaggedAPTARAEnd. Tomic D, Morton JI, Chen L, et al. Lifetime risk, life expectancy, and
            TaggedAPTARAPThis research was conducted using the UK Biobank
                                                                  years of life lost to type 2 diabetes in 23 high-income jurisdictions: A
         resource under application 29717. We thank the participants of  multinational, population-based study. Lancet Diabetes Endocrinol
         the UK Biobank and the China Kadoorie Biobank. There was  2022;10:795–803TaggedAPTARAEnd.
                                                               TaggedAPTARAListItem TaggedAPTARAListLabel5TaggedAPTARAEnd. American Diabetes Association Professional Practice Committee 5. Facil-
         no direct funding support for this work.TaggedAPTARAEnd
                                                                  itating behavior change and well-being to improve health outcomes:
                                                                  Standards of medical care in diabetes—2022. Diabetes Care 2022;45
         TaggedAPTARAH1Authors’ contributionsTaggedAPTARAEnd      (Suppl.1):S60–82TaggedAPTARAEnd.
                                                               TaggedAPTARAListItem TaggedAPTARAListLabel6TaggedAPTARAEnd. Barker J, Smith Byrne K, Doherty A, et al. Physical activity of UK adults
            TaggedAPTARAPJT conceived and designed the study, performed the statis-
                                                                  with chronic disease: Cross-sectional analysis of accelerometer-measured
         tical analysis, and drafted the first version of the manuscript;  physical activity in 96,706 UK Biobank participants. Int J Epidemiol
         ML curated parts of the data, interpreted the results, and  2019;48:1167–74TaggedAPTARAEnd.
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