Page 90 - 《运动与健康科学》(英文)2024年第2期

TaggedAPTARAEndTaggedAPTARAFigure Available online at www.sciencedirect.com

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Journal of Sport and Health Science 13 (2024) 212221

Original article

TaggedAPTARAH1Leisure-time physical activity and all-cause mortality and cardiovascular

disease in adults with type 2 diabetes: Cross-country comparison of

cohort studiesTaggedAPTARAEnd
a,
g
TaggedAPTARAPJakob Tarp *, Mengyun Luo b,c , Miguel Adriano Sanchez-Lastra d,e,f , Knut Eirik Dalene ,
k,l
a
Borja del Pozo Cruz h,i,j , Mathias Ried-Larsen , Reimar Wernich Thomsen ,
Ulf Ekelund d,g , Ding Ding b,c TaggedAPTARAEnd
a
TaggedAPTARAP Department of Clinical Epidemiology, Aarhus University & Aarhus University Hospital, Aarhus 8200, Denmark
b
Prevention Research Collaboration, Sydney School of Public Health, The University of Sydney, Camperdown, NSW 2006, Australia
c
Charles Perkins Centre, the University of Sydney, Camperdown, NSW 2050, Australia
d
Department of Sports Medicine, Norwegian School of Sports Sciences, Oslo 0806, Norway
e
Department of Special Didactics, Faculty of Education and Sports Sciences, University of Vigo, Pontevedra 36005, Spain
f Well-Move Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo 36213, Spain
g
Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo 0473, Norway
h
Centre for Active and Healthy Ageing, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense 5230, Denmark
i
Faculty of Education, University of C adiz, C adiz 11519, Spain
j
Biomedical Research and Innovation Institute of C adiz (INiBICA) Research Unit, Puerta del Mar University Hospital, University of C adiz, C adiz 11009, Spain
k
The Centre of Inflammation and Metabolism & the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark
l
Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense 5230, Denmark
TaggedAPTARAEnd Received 20 June 2023; revised 24 August 2023; accepted 12 September 2023
Available online 13 October 2023
2095-2546/Ó 2024 Published by Elsevier B.V. on behalf of Shanghai University of Sport. This is an open access article under the CC BY-NC-ND license.
(http://creativecommons.org/licenses/by-nc-nd/4.0/)
TaggedAPTARAPAbstract
Purpose: This study aimed to quantify the doseresponse association and the minimal effective dose of leisure-time physical activity (PA) to
prevent mortality and cardiovascular disease in adults with type 2 diabetes.
Methods: Cross-country comparison of 2 prospective cohort studies including 14,913 and 17,457 population-based adults with type 2 diabetes from
the UK and China. Baseline leisure-time PA was self-reported and categorized by metabolic equivalent hours per week (MET-h/week) according to
World Health Organization recommendations: none, below recommendation (>07.49 MET-h/week); at recommended level (7.514.9 MET-h/week);
above recommendation (15 MET-h/week). Mortality and cardiovascular disease data were obtained from national registries.
Results: During a median follow-up of 12.4 and 9.7 years, in the UK and China cohorts, repectively, higher levels of leisure-time PA were
inversely associated with all-cause (1571 and 2351 events) and cardiovascular mortality (392 and 1060 events), mostly consistent with a linear
doseresponse relationship. PA below, at, and above recommendations, compared with no activity, yielded all-cause mortality hazard ratios of
0.94 (95% confidence interval (95%CI): 0.791.12), 0.90 (95%CI: 0.741.10), and 0.85 (95%CI: 0.701.02) in British adults and 0.87
(95%CI: 0.681.10), 0.88 (95%CI: 0.741.03), and 0.77 (95%CI: 0.700.85) in Chinese adults. Associations with cardiovascular mortality
were more pronounced in British adults (0.80 (95%CI: 0.581.11), 0.75 (95%CI: 0.521.09), and 0.69 (95%CI: 0.480.97)) but less
pronounced in Chinese adults (1.06 (95%CI: 0.761.47), 1.01 (95%CI: 0.801.28), and 0.79 (95%CI: 0.690.92)). PA at recommended levels
was not associated with lower rates of major adverse cardiovascular events (2345 and 4458 events).
Conclusion: Leisure-time PA at the recommended levels was not convincingly associated with lower mortality and had no association with risk
of major adverse cardiovascular events in British or Chinese adults with type 2 diabetes. Leisure-time PA above current recommendations may
be needed to prevent cardiovascular disease and premature mortality in adults with type 2 diabetes.
TaggedAPTARAPKeywords: Complications; Epidemiology; Exercise; PreventionTaggedAPTARAEnd

TaggedAPTARAEndTaggedAPTARAEnd Peer review under responsibility of Shanghai University of Sport.
TaggedAPTARAEnd* Corresponding author.
E-mail address: jtarp@nih.no (J. Tarp).
https://doi.org/10.1016/j.jshs.2023.10.004
Cite this article: Tarp J, Luo M, Sanchez-Lastra MA, et al. Leisure-time physical activity and all-cause mortality and cardiovascular disease in adults with type 2
diabetes: Cross-country comparison of cohort studies. J Sport Health Sci 2024;13:21221.