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                    regulation  of  immune  cell  function  and  therapeutic  [38]   Kwon  J,  Bakhoum  SF.  The  cytosolic  DNA-sensing  cGAS-
                    implications[J]. J Immunol, 2022, 209(5): 845-854.  STING pathway in cancer[J]. Cancer Discov, 2020, 10(1): 26-
               [23]   Nguyen TA, Smith BRC, Elgass KD, et al. SIDT1 localizes to  39.
                    endolysosomes and mediates double-stranded RNA transport in-  [39]   Meric-Bernstam F, Sweis RF, Hodi FS, et al. Phase I dose-esca-
                    to the cytoplasm[J]. J Immunol, 2019, 202(12): 3483-3492.  lation  trial  of  MIW815  (ADU-S100),  an  intratumoral  STING
               [24]   Yuen MF, Chen CY, Liu CJ, et al. A phase 2, open-label, ran-  agonist,  in  patients  with  advanced/metastatic  solid  tumors  or
                    domized, multiple-dose study evaluating Inarigivir in treatment-  lymphomas[J]. Clin Cancer Res, 2022, 28(4): 677-688.
                    naïve patients with chronic hepatitis B[J]. Liver Int, 2023, 43(1):  [40]   Harrington KJ, Brody J, Ingham M, et al. LBA15 Preliminary
                    77-89.                                           results of the first-in-human (FIH) study of MK-1454, an ago-
               [25]   Moreno V, Gaudy-Marqueste C, Wermke M, et al. 794 Safety  nist of stimulator of interferon genes (STING), as monotherapy
                    and  efficacy  results  from  a  phase  1/1b  study  of  intratumoral  or  in  combination  with  pembrolizumab  (pembro)  in  patients
                    MK-4621, a retinoic acid-inducible gene I (RIG-I) agonist, plus  with advanced solid tumors or lymphomas[J]. Ann Oncol, 2018,
                    intravenous pembrolizumab in patients with advanced solid tu-  29: viii712.
                    mors[C]//Late-breaking  abstracts.  BMJ  Publishing  Group  Ltd,  [41]   Janku  F,  Luke  JJ,  Brennan  A,  et  al.  Abstract CT110:   Intratu-
                    2020: A474.2-A475.                               moral injection of SYNB1891, a synthetic biotic designed to ac-
               [26]   Lamoot A, Jangra S, Laghlali G, et al. Lipid nanoparticle encap-  tivate the  innate  immune  system,  demonstrates  target   engage-
                    sulation empowers poly(I: C) to activate cytoplasmic RLRs and  ment  in  humans  including  intratumoral  STING  activation[J].
                    thereby  increases  its  adjuvanticity[J].  Small,  2024,  20(10):  Cancer Res, 2021, 81(13_Supplement): CT110.
                    e2306892.                                   [42]   Feng XD, Lin J, Jang SC, et al. 761 exoSTING demonstrates
               [27]   Steinberg GD, Kalota SJ, Lotan Y, et al. Clinical results of a  potent anti-tumor activity in a mouse model of leptomeningeal
                    phase 1 study of intravesical EG-70 in patients with BCG-unre-  disease[C]//Regular  and  Young  Investigator  Award  Abstracts.
                    sponsive NMIBC[J]. J Clin Oncol, 2023, 41(6_suppl): 512.  BMJ Publishing Group Ltd, 2021: A796-A796.
               [28]   Gokhale NS, Sam RK, Somfleth K, et al. Cellular RNA inter-  [43]   Foldi J, Piha-Paul SA, Villaruz LC, et al. A phase 1 dose-esca-
                    acts  with  MAVS  to  promote  antiviral  signaling[J].  Science,  lation  and  expansion  study  of  an  intratumorally  administered
                    2024, 386(6728): eadl0429.                       dual STING agonist (ONM-501) alone and in combination with
               [29]   Ashley CN, Broni E, Miller WA 3rd. ADAR family proteins: a  cemiplimab in  patients  with  advanced  solid  tumors  and   lym-
                    structural review[J]. Curr Issues Mol Biol, 2024, 46(5): 3919-  phomas[J]. J Clin Oncol, 2024, 42(16_suppl): TPS2693.
                    3945.                                       [44]   Luke J J, Pinato D J, Juric D, et al. Phase I dose-escalation and
               [30]   Vogel  OA,  Han  J,  Liang  CY,  et  al.  The  p150  isoform  of  pharmacodynamic study of STING agonist E7766 in advanced
                    ADAR1 blocks sustained RLR signaling and apoptosis during  solid tumors[J]. J Immunothera Cancer, 2025, 13(2): e010511.
                    influenza  virus  infection[J].  PLoS  Pathog,  2020,  16(9):  [45]   Pelka K, Shibata T, Miyake K, et al. Nucleic acid-sensing TLRs
                    e1008842.                                        and autoimmunity: novel insights from structural and cell biolo-
               [31]   Wang X, Li JX, Zhu YS, et al. Targeting ADAR1 with a small  gy[J]. Immunol Rev, 2016, 269(1): 60-75.
                    molecule  for  the  treatment  of  prostate  cancer[J].  Nat  Cancer,  [46]   Alzahrani B. The biology of toll-like receptor 9 and its role in
                    2025, 6(3): 474-492.                             cancer[J]. Crit Rev Eukaryot Gene Expr, 2020, 30(5): 457-474.
               [32]   Patrick KL, Bell SL, Watson RO. For better or worse: cytosolic  [47]   Gies V, Bekaddour N, Dieudonné Y, et al. Beyond anti-viral ef-
                    DNA sensing during intracellular bacterial infection induces po-  fects  of  chloroquine/hydroxychloroquine[J].  Front  Immunol,
                    tent  innate  immune  responses[J].  J  Mol  Biol,  2016,  428(17):  2020, 11: 1409.
                    3372-3386.                                  [48]   Borazanci EH, Jameson GS, Snyder CE, et al. Paclitaxel pro-
               [33]   Nakamura M, Takada T, Yamana K. Controlling Pyrene associ-  tein bound (A) plus gemcitabine (G) plus cisplatin (C) and hy-
                    ation in DNA duplexes by B- to Z-DNA transitions[J]. Chem-  droxychloroquine (HCQ) neoadjuvant therapy for localized pan-
                    biochem, 2019, 20(23): 2949-2954.                creatic ductal adenocarcinoma (PDAC)[J]. J Clin Oncol, 2024,
               [34]   Smirnov E, Molínová P, Chmúrčiaková N, et al. Non-canonical  42(3_suppl): 667.
                    DNA  structures  in  the  human  ribosomal  DNA[J].  Histochem  [49]   Ribas A, Milhem MM, Hoimes CJ, et al. Phase 1b/2, open la-
                    Cell Biol, 2023, 160(6): 499-515.                bel, multicenter, study of the combination of SD-101 and pem-
               [35]   Liu  SD.  Protein  tyrosine  phosphorylation  in  innate  immune  brolizumab in patients with advanced melanoma who are naïve
                    sensing of cytosolic nucleic acids [D]. Hangzhou: Zhejiang Uni-  to  anti-PD-1  therapy[J].  J  Clin  Oncol,  2018,  36(15_suppl):
                    versity, 2019.                                   9513.
               [36]   Lou  FN,  Zheng  MY,  Chen  KX,  et  al.  Research  progress  of  [50]   Paller AS, Browning J, Nikolic M, et al. Efficacy and tolerabili-
                    cGAS-STING signaling  pathway  modulators  in   immunothera-  ty of the investigational topical cream SD-101 (6% allantoin) in
                    py[J]. J China Pharm Univ (中国药科大学学报), 2024, 55(1):  patients  with  epidermolysis  bullosa:  a  phase  3,  randomized,
                    15-25.                                           double-blind, vehicle-controlled trial (ESSENCE study)[J]. Or-
               [37]   Decout A, Katz J D, Venkatraman S, et al. The cGAS–STING  phanet J Rare Dis, 2020, 15(1): 158.
                    pathway as a therapeutic target in inflammatory diseases[J]. Na-  [51]   Atreya R, Reinisch W, Peyrin-Biroulet L, et al. Clinical effica-
                    ture Reviews Immunology, 2021, 21(9): 548-569.   cy of the Toll-like receptor 9 agonist cobitolimod using patient-
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