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第  56 卷第  4 期                        周 珂,等:疟疾疫苗的研发进展                                       537

               改进免疫原结构和优化蛋白质合成来发现、验证新                                length  Plasmodium  falciparum  merozoite  surface  protein  1  is
               的抗原和递送系统,提高候选疫苗的保护效力和持                                safe and elicits functional cytophilic antibodies in a randomized
                                                                     first-in-human trial[J]. NPJ Vaccines, 2020, 5(1): 10.
               久性,进一步降低疟疾发病率和病死率,达到保护                           [16]   Rosenkranz  M,  Fürle  K,  Hibbert  J,  et  al.  Multifunctional
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