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TaggedFigure TaggedEndSitting and physical activity with adult body fat                               201











































           Fig. 2. Joint association of daily sitting time and leisure-time physical activity with trunk body fat percentage among U.S. adults by sex, NHANES 20112018.
           Joint association of daily sitting time (h/day) and leisure-time physical activity (min/week) with trunk fat percentage within each subgroup: (A) male and (B)
           female. Estimates were adjusted for age (year), sex (male or female), race (non-Hispanic White, non-Hispanic Black, Hispanic, or other), educational attainment
           (less than high school, high school graduate, or above high school), family poverty ratio (<1.3, 1.3 to <3.5, or 3.5), smoking status (never, former, or current),
           alcohol use (never, former, or current), total energy intake and Healthy Eating Index-2015, hypertension (yes or no), hypercholesterolemia (yes or no), history of
           diabetes (yes or no), history of CVD (yes or no), history of cancer (yes or no), and depression (yes or no). 95%CI = 95% confidence interval; CVD = cardiovascular
           disease; NHANES = National Health and Nutrition Examination Survey.TaggedEnd


           and body fat. A mendelian randomization study found a bidirec-  insufficiently active adults who spent more than 8 h/day sitting
           tional, causal relationship between sedentary time and body  tended to have the highest percentage of body fat. Our results
           mass index, which highlights not only that limiting sedentary  agree with those of a previous review which suggested that
           time is beneficial for weight control, but that fat loss may also  68 h/day of total sitting (self-reported) was a threshold for
           lead to reduced sedentary time. 48  Altogether with our findings,  increased risk of both all-cause and CVD mortality after
           clinicians, health professionals, and policy makers need to  adjusting for physical activity. 49  Additionally, our findings
           develop effective strategies to target obese adults who spend a  using the categorization of physical activity strongly supported
                                                                 current national and international guidelines on physical
           prolonged amount of time sitting.TaggedEnd
             TaggedPThe new 2020 World Health Organization Global Guide-  activity. In particular, the prevalence of obese and overweight
           lines on Physical Activity and Sedentary Behavior underscore  adults is strikingly high in the United States. Although the
           the need to promote physical activity among adults and, for  2018 Physical Activity Guidelines for Americans acknowl-
           the first time, include guidelines for sedentary behaviors (but  edged for the first time the health risks associated with seden-
           without a specific threshold, due to limited quantified evidence  tary behaviors, they were not able to specify or quantify
           with respect to health outcomes). 11  The present study  recommendations for sedentary time. Our findings could
           suggested a doseresponse association between total sitting  inform evidence-based strategies to reduce the burden of
           time and body fat percentage. The significant increase in body  obesity by increasing physical activity and decreasing seden-
           fat percentage (total and trunk) was observed starting with  tary behaviors in the United States.TaggedEnd
           68 h/day of sitting among adults who achieved at least  TaggedPThe study has several strengths. It included a large, nation-
           150 min/week of LTPA and with any amount of sitting for  ally representative sample of U.S. adults, which allowed our
           those engaged in less than 150 min/week of LTPA. Inactive or  findings to be generalizable at the population level. Further,
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