Page 82 - 《运动与健康科学》(英文)2024年第2期

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Journal of Sport and Health Science 13 (2024) 204211

Original article

TaggedAPTARAH1Association of physical activity with risk of chronic kidney disease in China:

A population-based cohort studyTaggedAPTARAEnd
a
a
b
TaggedAPTARAPKexiang Shi , Yunqing Zhu , Jun Lv a,b,c , Dianjianyi Sun a,b,c , Pei Pei , Huaidong Du d,e ,
f
d
d
g
Yiping Chen d,e , Ling Yang d,e , Bing Han , Rebecca Stevens , Junshi Chen , Zhengming Chen ,
Liming Li a,b,c , Canqing Yu a,b,c, *TaggedAPTARAEnd, on behalf of China Kadoorie Biobank collaborative group y
a
TaggedAPTARAP Department of Epidemiology & Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China
b
Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China
c
Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing 100191, China
d
Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK
e
Medical Research Council Population Health Research Unit at the University of Oxford, Oxford OX3 7LF, UK
f
NCDs Prevention and Control Department, Henan Center for Disease Control and Prevention, Zhengzhou 450016, China
g
China National Center for Food Safety Risk Assessment, Beijing 100022, China
TaggedAPTARAEnd Received 20 March 2023; revised 29 May 2023; accepted 6 July 2023
Available online 31 July 2023
2095-2546/Ó 2024 Published by Elsevier B.V. on behalf of Shanghai University of Sport. This is an open access article under the CC BY-NC-ND license.
(http://creativecommons.org/licenses/by-nc-nd/4.0/)
TaggedAPTARAPAbstract
Background: Information on the association between physical activity (PA) and the risk of chronic kidney disease (CKD) is limited. We aimed to
explore the associations of total, domain-specific, and intensity-specific PA with CKD and its subtypes in China.
Methods: The study included 475,376 adults from the China Kadoorie Biobank aged 3079 years during 20042008 at baseline. An interviewer-ad-
ministered questionnaire was used to collect the information about PA, which was quantified as metabolic equivalent of task hours per day (MET-h/day)
and categorized into 4 groups based on quartiles. Cox regression was used to analyze the association between PA and CKD risk.
Results: During a median follow-up of 12.1 years, 5415 incident CKD cases were documented, including 1159 incident diabetic kidney disease (DKD)
cases and 362 incident hypertensive nephropathy (HTN) cases. Total PA was inversely associated with CKD risk, with an adjusted hazard ratio (HR,
95% confidence interval (95%CI)) of 0.83 (0.750.92) for incident CKD in the highest quartile of total PA as compared with participants in the lowest
quartile. Similar results were observed for risk of DKD and HTN, and the corresponding HRs (95%CIs) were 0.75 (0.580.97) for DKD risk and 0.56
(0.370.85) for HTN risk. Increased nonoccupational PA, low-intensity PA, and moderate-to-vigorous-intensity PA were significantly associated with
a decreased risk of CKD, with HRs (95%CIs) of 0.80 (0.730.88), 0.85 (0.770.94), and 0.85 (0.760.95) in the highest quartile, respectively.
Conclusion: PA, including nonoccupational PA, low-intensity PA, and moderate-to-vigorous-intensity PA, was inversely associated with the risk
of CKD, including DKD, HTN, and other CKD, and such associations were dose dependent.
TaggedAPTARAPKeywords: Chronic kidney disease; Domain; Intensity; Physical activityTaggedAPTARAEnd

rise from 16th to 5th place among the leading causes of
TaggedAPTARAH11. IntroductionTaggedAPTARAEnd
1
premature death between 2016 and 2040. In 2016, the
TaggedAPTARAPChronic kidney disease (CKD) has been a major public
global prevalence of CKD hit 13.4%. In recent years, the
health problem worldwide and is closely associated with
incidenceofCKD hasbeenincreasingindevelopingcoun-
the risk of a range of adverse outcomes, including cardio-
tries due to the significant increase in non-communicable
vascular events and death. It is predicted that CKD will 2
diseases, particularly diabetes and hypertension. According
to the Chinese Kidney Disease Scientific Report, CKD
TaggedAPTARAEndTaggedAPTARAEnd Peer review under responsibility of Shanghai University of Sport. includes 5 major subtypes, among which diabetic kidney
TaggedAPTARAEnd* Corresponding author.
E-mail address: yucanqing@pku.edu.cn (C. Yu). disease (DKD) and hypertensive nephropathy (HTN) are
y 3
TaggedAPTARAEnd The members of the steering committee and collaborative group are listed prevalent in urban areas of China. TaggedAPTARAEnd
in the online-only supplementary materials.
https://doi.org/10.1016/j.jshs.2023.07.004
Cite this article: Shi K, Zhu Y, Lv J, et al. Association of physical activity with risk of chronic kidney disease in China: A population-based cohort study.
J Sport Health Sci 2024;13:20411.