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李伟嘉，等 水产学报, 2025, 49(12): 129602

seipin 对 MTP 多种功能的调控，但具体机制仍 Biology, 2022, 29(3): 194-202
有待进一步探究。 [ 9 ] Prasanna, X, Salo, V T, Li, S, et al. seipin traps triacylglycerols
在 TG 分解方面，甘油三酯脂肪酶 (ATGL)
to facilitate their nanoscale clustering in the endoplasmic retic-
和脂蛋白酯酶 (LPL) 都是 TG 分解的关键酶。
ulum membrane[J]. PLoS Biology, 2021, 19(1): e3000998
seipin 敲除小正常饮食状态下肝脏和心肌 atgl 表
[10] Payne, V A, Grimsey, N, Tuthill, A, et al. The human lipodys-
达降低 [30-31] ，斑马鱼中干扰 seipin 表达后肝脏
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atgl 和 lpl 表达量表达量的降低亦可能通过抑制
cyte differentiation[J]. Diabetes, 2008, 57(8): 2055-2060
脂解使 TG 含量升高。因此，敲降 seipin 可能通
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鱼肝脏脂质代谢；短时间过表达 seipin 可能抑 storage through the ER Ca -ATPase SERCA[J]. Cell Metabol-
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