Page 11 - 《中国医疗器械杂志》2025年第2期

Chinese Journal of Medical Instrumentation 2025 年 第49卷 第2期

研 究 与 论 著

文章编号：1671-7104(2025)02-0125-09

花瓣结构电极用于脉冲消融下心肌组织消融效果研究

【作 者】 陆凌峰 ，陈惠铭 1,2
1,2
1 上海市医疗器械检验研究院，上海市，201318
2 国家药品监督管理局医用电气设备重点实验室，上海市，201318
【摘 要】 该研究旨在评估花瓣结构电极在脉冲电场消融（pulsed field ablation, PFA）技术中的应用效果，特别是其在
心肌组织消融中的表现。通过将仿真技术与体外实验相结合，探讨了不同电压、电极与组织接触距离对消
融深度、连续性及透壁效果的影响。研究方法包括构建心肌组织仿真模型，使用COMSOL Multiphysics进
行电场分布仿真，并进行马铃薯组织的体外消融实验。结果表明，随着电压的增大，消融深度显著增加；当
电压达到2 500 V时，能够实现4 mm的透壁消融深度，且消融区域较为连续。体外实验验证了仿真结果的一
致性，且脉冲电场消融未引起显著温升，证实了其非热特性。结论指出，PFA技术具有较低的电极接触要
求和较高的消融效率，为临床治疗房颤提供了新的技术路径，能够有效降低传统消融技术的并发症风险。
【关 键 词】 房颤；脉冲电场消融；花瓣结构；心肌组织
【中图分类号】 R318
【文献标志码】 A doi: 10.12455/j.issn.1671-7104.240484
Simulation Study of Myocardial Tissue Ablation Effects Using Flower
Petal-Structured Electrodes in Pulsed Ablation
1,2
【 Authors 】 LU Lingfeng , CHEN Huiming 1,2
1 Shanghai Institute of Medical Device Testing, Shanghai, 201318
2 NMPA Key Laboratory for Medical Electrical Equipment, Shanghai, 201318
【 Abstract 】 This study aims to evaluate the application of flower petal-structured electrodes in pulsed field ablation
(PFA) technology, with a particular focus on their performance in myocardial tissue ablation. Through a
combination of simulation techniques and in vitro experiments, the study investigates the effects of
different voltage levels, electrode-to-tissue contact distances, and their impact on ablation depth,
continuity, and transmurality. The research methods include the construction of a myocardial tissue
simulation model, electric field distribution simulation using COMSOL Multiphysics, and in vitro ablation
experiments on potato tissue. The results indicate that as voltage increases, the ablation depth
significantly increases. At a voltage of 2 500 V, a transmural ablation depth of 4 mm can be achieved, and
the ablation area remains relatively continuous. The in vitro experiments confirm the consistency of the
simulation results, and pulsed field ablation does not induce significant temperature rise, confirming its
non-thermal characteristic. The conclusion suggests that PFA technology requires less electrode contact
and offers higher ablation efficiency, providing a new technological pathway for the clinical treatment of
atrial fibrillation and effectively reducing the risk of complications associated with traditional ablation
techniques.
【Key words】 atrial fibrillation, pulsed field ablation, flower petal-structured, myocardial tissue

0 引言 床诊断中最常见的室上性快速性心律失常疾病。

1998年，HAÏSSAGUERRE等 的突破性研究确认
[1]
心房颤动（以下简称房颤）被广泛认定为临
了94％的心房异常起搏点源自肺静脉，这项发现将
收稿日期：2024-09-04 肺静脉隔离（pulmonary vein isolation, PVI）确立
作者简介：陆凌峰，E-mail: 13764948912@sina.cn
通信作者：陈惠铭，E-mail: cmtcchm@163.com 为治疗房颤的基本策略。应用于PVI的主要消融技

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