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132                      学报   Journal of China Pharmaceutical University 2026, 57(1): 122 − 132  第 57 卷

               [22]   Caruso A, Martinie RJ, Bushin LB, et al. Macrocyclization via  15(8): 2221-2231.
                    an  arginine-tyrosine  crosslink  broadens  the  reaction  scope  of  [38]   Phan  CS,  Morinaka  BI.  A  prevalent  group  of  actinobacterial
                    radical  S-adenosylmethionine  enzymes[J].  J  Am  Chem  Soc,  radical SAM/SPASM maturases involved in triceptide biosyn-
                    2019, 141(42): 16610-16614.                      thesis[J]. ACS Chem Biol, 2022, 17(12): 3284-3289.
               [23]   Sugiyama R, Suarez AFL, Morishita Y, et al. The biosynthetic  [39]   Khan AH, Haedar JR, Kiselov V, et al. Radical SAM enzyme
                    landscape of triceptides reveals radical SAM enzymes that cat-  WprB  catalyzes  uniform  cross-link  topology  between  Trp-C5
                    alyze  cyclophane  formation  on  Tyr-  and  his-containing  and Arg-Cγ on the precursor peptide[J]. ACS Chem Biol, 2025,
                    motifs[J]. J Am Chem Soc, 2022, 144(26): 11580-11593.  20(2): 259-265.
               [24]   He BB, Cheng Z, Zhong Z, et al. Expanded sequence space of  [40]   Purushothaman M, Chang LT, Zhong RJ, et al. The triceptide
                    radical  S-adenosylmethionine-dependent  enzymes  involved  in  maturase OscB catalyzes uniform cyclophane topology and ac-
                    post-translational  macrocyclization[J].  Angew  Chem  Int  Ed,  cepts  diverse  Gly-rich  precursor  peptides[J].  ACS  Chem  Biol,
                    2022, 61(48): e202212447.                        2024, 19(6): 1229-1236.
               [25]   Phan CS, Chang LT, Nguyen TQN, et al. Substrate promiscuity  [41]   Nguyen TQN, Tooh YW, Sugiyama R, et al. Post-translational
                    of the triceptide maturase XncB leads to incorporation of vari-  formation  of  strained  cyclophanes  in  bacteria[J].  Nat  Chem,
                    ous amino acids and detection of oxygenated products[J]. ACS  2020, 12(11): 1042-1053.
                    Chem Biol, 2024, 19(4): 855-860.            [42]   Bushin LB, Clark KA, Pelczer I, et al. Charting an unexplored
               [26]   Nanudorn P, Thiengmag S, Biermann F, et al. Atropopeptides  streptococcal  biosynthetic  landscape  reveals  a  unique  peptide
                    are a novel family of ribosomally synthesized and posttransla-  cyclization  motif[J].  J  Am  Chem  Soc,  2018,  140(50):  17674-
                    tionally modified peptides with a complex molecular shape[J].  17684.
                    Angew Chem Int Ed, 2022, 61(41): e202208361.  [43]   Biermann F, Tan B, Breitenbach M, et al. Exploration, expan-
               [27]   Treisman M, Coe L, Zhao YW, et al. An engineered biarylitide  sion and definition of the atropopeptide family of ribosomally
                    cross-linking P450  from  RiPP  biosynthesis  generates   alterna-  synthesized and posttranslationally modified peptides[J]. Chem
                    tive cyclic peptides[J]. Org Lett, 2024, 26(9): 1828-1833.  Sci, 2024, 15(42): 17506-17523.
               [28]   He BB, Liu J, Cheng Z, et al. Bacterial cytochrome P450 cat-  [44]   Hu YL, Yin FZ, Shi J, et al. P450-modified ribosomally synthe-
                    alyzed  post-translational macrocyclization  of  ribosomal   pep-  sized  peptides  with  aromatic  cross-links[J].  J  Am  Chem  Soc,
                    tides[J]. Angew Chem Int Ed, 2023, 62(46): e202311533.  2023, 145(50): 27325-27335.
               [29]   Saito  S,  Atsumi  K,  Zhou  T,  et  al.  A  cyclopeptide  and  three  [45]   Bushin LB, Covington BC, Clark KA, et al. Bicyclostreptins are
                    oligomycin-class  polyketides  produced  by  an  underexplored  radical  SAM  enzyme-modified peptides  with  unique   cycliza-
                    actinomycete  of  the  genus  Pseudosporangium[J].  Beilstein  J  tion motifs[J]. Nat Chem Biol, 2022, 18(10): 1135-1143.
                    Org Chem, 2020, 16: 1100-1110.              [46]   Nesic  M,  Ryffel  DB,  Maturano  J,  et  al.  Total  synthesis  of
               [30]   Phan CS, Morinaka BI. Bacterial cyclophane-containing RiPPs  darobactin A[J]. J Am Chem Soc, 2022, 144(31): 14026-14030.
                    from radical SAM enzymes[J]. Nat Prod Rep, 2024, 41(5): 708-  [47]   Woodard AM, Peccati F, Navo CD, et al. Darobactin substrate
                    720.                                             engineering  and  computation  show  radical  stability  governs
               [31]   Nguyen BX, Gurusinga FF, Mettal U, et al. Radical-mediated  ether  versus  C-C  bond  formation[J].  J  Am  Chem  Soc,  2024,
                    nucleophilic peptide cross-linking in dynobactin biosynthesis[J].  146(20): 14328-14340.
                    J Am Chem Soc, 2024, 146(46): 31715-31732.  [48]   Padva L, Gullick J, Coe LJ, et al. The biarylitides: understand-
               [32]   Yu LH, Nagata Y, Nakamura H. Atroposelective total synthesis  ing the structure and biosynthesis of a fascinating class of cy-
                    of cihunamide B[J]. J Am Chem Soc, 2024, 146(4): 2549-2555.  tochrome  P450  modified  RiPP  natural  products[J].  Chem-
               [33]   Hug JJ, Frank NA, Walt C, et al. Genome-guided discovery of  biochem, 2025, 26(7): e202400916.
                    the first myxobacterial biarylitide myxarylin reveals distinct C-  [49]   Zdouc MM, Alanjary MM, Zarazúa GS, et al. A biaryl-linked
                    N biaryl crosslinking in RiPP biosynthesis[J]. Molecules, 2021,  tripeptide from Planomonospora reveals a widespread class of
                    26(24): 7483.                                    minimal  RiPP  gene  clusters[J].  Cell  Chem  Biol,  2021,  28(5):
               [34]   Liu  J,  Liu  RZ,  He  BB,  et  al.  Bacterial cytochrome  P450   cat-  733-739. e4.
                    alyzed macrocyclization of ribosomal peptides[J]. ACS Bio Med  [50]   Zhao YW, Marschall E, Treisman M, et al. Cytochrome P450 Blt
                    Chem Au, 2024, 4(6): 268-279.                    enables  versatile  peptide  cyclisation  to  generate  histidine-  and
               [35]   Nguyen H, Made Kresna ID, Böhringer N, et al. Characteriza-  tyrosine-containing  crosslinked  tripeptide  building  blocks[J].
                    tion of a radical SAM oxygenase for the ether crosslinking in  Angew Chem Int Ed, 2022, 61(37): e202204957.
                    darobactin  biosynthesis[J].  J  Am  Chem  Soc,  2022,  144(41):  [51]   Ritzmann N, Manioglu S, Hiller S, et al. Monitoring the antibi-
                    18876-18886.                                     otic  darobactin  modulating  the  β-barrel  assembly  factor
               [36]   Liu CL, Wang ZJ, Shi J, et al. P450-modified multicyclic cyclo-  BamA[J]. Structure, 2022, 30(3): 350-359. e3.
                    phane-containing ribosomally synthesized and post-translation-  [52]   Miller RD, Iinishi A, Modaresi SM, et al. Computational identi-
                    ally  modified  peptides[J].  Angew  Chem  Int  Ed,  2024,  63(10):  fication  of  a  systemic  antibiotic  for  gram-negative  bacteria[J].
                    e202314046.                                      Nat Microbiol, 2022, 7(10): 1661-1672.
               [37]   Hug JJ, Dastbaz J, Adam S, et al. Biosynthesis of cittilins, un-  [53]   Zhong  GN.  Cytochromes P450  associated  with  the   biosynthe-
                    usual ribosomally synthesized and post-translationally modified  ses  of  ribosomally  synthesized  and  post-translationally  modi-
                    peptides  from  Myxococcus  xanthus[J].  ACS  Chem  Biol,  2020,  fied peptides[J]. ACS Bio Med Chem Au, 2023, 3(5): 371-388.
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