Page 90 - 《中国药科大学学报》2025年第5期

622 学报 Journal of China Pharmaceutical University 2025, 56(5): 613 − 623 第 56 卷

槐素显著地上调了 MITF 和 TYR 的表达水平，可见 成本较高，而藏茴香作为药食同源天然成分药物不
刺槐素可通过激活 MITF 转录因子，从而促进 TYR 良反应更低，价格更低廉，可作为抗白癜风药物长
的表达，进一步达到促进黑素合成的作用（图 7）。 期使用。但本研究仅分析了藏茴香中单一化合物
在现有的白癜风治疗手段中，糖皮质激素类药 刺槐素的作用机制，仍需对中药藏茴香的多组分协
[22]
物有皮肤萎缩的风险 ，JAK 抑制剂（如托法替尼） 同治疗进行研究。

Figure 7 Mechanism of acacetin in promoting melanogenesis via MITF and TYR regulation

seeds and its biological activities[D]. Beijing: University of Chi-
References
nese Academy of Sciences, 2023.
[1] Li SJ, Shen ND, Zhu HQ. Analysis of nutrient components in [8] Wahefu A, Abdulla R, Lu XY, et al. Chemical profiling of com-
leaves of 42 germplasm resources of Carum carvi[J]. J Anhui posite prescription caraway and quantification of three pairs iso-
Agric Sci(安徽农业科学), 2022, 50(3): 194-197. meric components in caraway administered rat plasma by tan-
[2] Tomasello G, Palumbo V D, Sinagra E, et al. A mixture of veg- dem mass spectrometry[J]. J Sep Sci, 2022, 45(16): 3082-3094.
etable extracts (chamomile, passionflower, caraway, fennel) and [9] Wang LJ, Peng F, Zhao ZW, et al. Study on the analysis of
enzymes (beta-galactosidase) for Irritable Bowel Syndrome blood-entering components of tibetan medicine “Jinidexie”
(IBS): an observational study ("BIOVES")[J]. Prog Nutr, 2018, based on UPLC-Q-Exactive Orbitrap MS technology[J]. J
20(3): 526-531. Chengdu Univ Tradit Chin Med (成都中医药大学学报), 2025,
[3] Kim JY, Kim JY, Park JY, et al. Synergistic bactericidal effects 48(1): 47-54.
of carvone and β-lactams against Xanthomonas campestris pv. [10] Ahn MJ, Hur SJ, Kim EH, et al. Scopoletin from Cirsium seti-
vesicatoria[J]. Appl Biol Chem, 2023, 66(1): 44. dens increases melanin synthesis via CREB phosphorylation in
[4] Bourgou S, Bettaieb Rebey I, Dakhlaoui S, et al. Green extrac- B16F10 cells[J]. Korean J Physiol Pharmacol, 2014, 18(4):
tion of oil from Carum carvi seeds using bio-based solvent and 307-311.
supercritical fluid: Evaluation of its antioxidant and anti-inflam- [11] Ozdemir E, Demirkazik A, Gursoy S, et al. Effects of extreme-
matory activities[J]. Phytochem Anal, 2020, 31(1): 37-45. ly low frequency electromagnetic fields on morphine analgesia
[5] Es-Safi I, Mechchate H, Amaghnouje A, et al. An insight into and tolerance in rats[J]. Gen Physiol Biophys, 2017, 36(4): 415-
the anxiolytic and antidepressant-like proprieties of Carum 422.
carvi L. and their association with its antioxidant activity[J]. [12] Shao Q, Zhao Y, Shi YY, et al. Chemical characterization of
Life (Basel), 2021, 11(3): 207. Siraitia grosvenorii granules and their efficacy and mechanism
[6] Maimaitiyiming Wubulikasimu. Treatment of vitiligo with ti- of action on PM 2.5 -induced acute lung injury[J]. Ecotoxicol Env-
betan cumin preparation[J]. J Med Pharm Chin Minor (中国民 iron Saf, 2025, 290: 117702.
族医药杂志), 2006(4): 92. [13] Zymone K, Raudone L, Žvikas V, et al. Phytoprofiling of Sor-
[7] Liu CH. Studies on chemical constituents of Carum carvi L. bus L. inflorescences: a valuable and promising resource for