Page 119 - 《中国药科大学学报》2025年第4期

学报
Journal of China Pharmaceutical University 2025, 56(4): 515 − 523 515

桦褐孔菌化学成分及药理活性研究进展

崔佳敏，范海然，蒯海敏，胡晓龙，汪 豪 *

（中国药科大学中药学院, 南京 210009）

摘 要 桦褐孔菌为一种药食两用真菌，在俄罗斯、日本和中国东北民间已有悠久的药用及食用历史。桦褐孔菌含有萜类、
甾体、多糖、酚类及生物碱等化合物，具有抗肿瘤、降血糖、抗炎、抗氧化和降脂等药理活性，其中，羊毛甾烷型四环三萜为其特
征性成分。本文系统综述了近年从桦褐孔菌中分离鉴定的化学成分及药理活性研究进展，整理并绘制了萜类、甾体及酚类化
合物的结构，重点总结了羊毛甾烷型四环三萜的骨架类型和结构特征，为桦褐孔菌的深入研究与综合开发利用提供参考。
关键词 桦褐孔菌；化学成分；羊毛甾烷型三萜；药理活性
中图分类号 R284 文献标志码 A 文章编号 1000−5048(2025)04−0515−09
doi：10.11665/j.issn.1000−5048.2024051101

引用本文 崔佳敏，范海然，蒯海敏，等. 桦褐孔菌化学成分及药理活性研究进展 [J]. 中国药科大学学报，2025，56（4）：515 − 523.

Cite this article as: CUI Jiamin, FAN Hairan, KUAI Haimin, et al. Research progress in chemical constituents and pharmacological activities
of Inonotus obliquus[J]. J China Pharm Univ, 2025, 56(4): 515 − 523.

Research progress in chemical constituents and pharmacological activities of
Inonotus obliquus
CUI Jiamin, FAN Hairan, KUAI Haimin, HU Xiaolong, WANG Hao *
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China

Abstract As a medicinal and edible fungus, Inonotus obliquus has a long history of folk application in Russia,
Japan, and Northeast China. It is rich in terpenoids, steroids, polysaccharides, phenols, alkaloids, etc, and exhibits
pharmacological activities including anti-tumor, hypoglycemic, anti-inflammatory, antioxidant, and lipid-
lowering effects. Among these, lanostane-type tetracyclic triterpenes represent its characteristic constituents. This
review systematically summarizes the research progress on the chemical components isolated and identified from
I. obliquus and their pharmacological activities in recent years. The structures of terpenoids, steroids, and
phenolic compounds are compiled and illustrated, with a particular focus on the skeletal types and structural
characteristics of lanostane-type tetracyclic triterpenes. This work aims to provide some reference for the further
investigation and comprehensive development and utilization of I. obliquus.
Key words Inonotus obliquus; chemical constituents; lanostane-type triterpenoids; pharmacological activity

This study was supported by the Major Science and Technology Special Projects of Yunnan Province (202402AA310001); the
Yunnan Expert Workstation Project (202305AF150096); and the Diqing Government-China Pharmaceutical University State and
School Cooperation Project

桦褐孔菌 (Inonotus obliquus) 属担子菌亚门 chaetaceae)、纤孔菌属 (Inonotus)，是一种常寄生于

(Basidiomycotina)、层菌纲 (Hymenomycetes)、锈革 白桦树、榆树、银桦、赤杨等落叶树的树皮或枝干
孔菌目 (Hymenochaetales)、锈革孔菌科 (Hymeno- 上的木腐真菌 [1−2] 。桦褐孔菌主要分布于北半球北纬

收稿日期 2024-05-11 * 通信作者 Tel：025-83271328 E-mail：wanghao@cpu.edu.cn
基金项目 云南省重大科技专项 (202402AA310001)；云南省专家工作站项目 (202305AF150096)；迪庆州－中国药科大学州校合作项目