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778 渔 业 研 究 第 47 卷

［ 8 ］ Melnikova D I, Khotimchenko Y S, Magarlamov T Y. bution of tetrodotoxin in the ribbon worm Lineus al-
Addressing the issue of tetrodotoxin targeting[J]. Mar- borostratus (Takakura, 1898) (nemertea): immunoelec-
ine Drugs, 2018, 16(10): 352. tron and immunofluorescence studies[J]. Toxicon, 2016,
［ 9 ］ 李惠冬，储智勇，钱晓明，等. 反毒为药：精准控制 112: 29 − 34.
河鲀毒素用作局部麻醉药的新进展 [J]. 生物化学与 ［18］ Vaelli P M, Theis K R, Williams J E, et al. The skin mi-
生物物理进展，2021，48（9） ：1031 − 1041. crobiome facilitates adaptive tetrodotoxin production in
Li H D, Chu Z Y, Qian X M, et al. From poison to po- poisonous newts[J]. eLife, 2020, 9: e53898.
tion: new progress in precise control of tetrodotoxin as a ［19］ 杜晟. 产河豚毒素细菌的分离鉴定及弧菌群体感应元
local anesthetic[J]. Progress in Biochemistry and Bio- 件 LuxR 对细菌河豚毒素产量的影响 [D]. 上海：上
physics, 2021, 48(9): 1031 − 1041. 海海洋大学，2023.
［10］ 陈素青，任雷鸣，黄致强. 河豚毒素对大鼠和小鼠纳 Du S. Isolation and identification of tetrodotoxin-produ-
洛酮催促吗啡戒断症状的影响 [J]. 中国药理学与毒 cing bacteria and the effect of Vibrio quorum sensing

理学杂志，2001，15（6） ：434 − 440. element LuxR on production of tetrodotoxin[D]. Shang-
Chen S Q, Ren L M, Huang Z Q. Effects of tetrodotoxin hai: Shanghai Ocean University, 2023.
on naloxone-precipitated withdrawal syndrome in mor- ［20］ 张宏宇，林涛，武斌，等. 产河豚毒素菌株的筛选、
phine-dependent rats and mice[J]. Chinese Journal of 鉴定及透析培养 [J]. 应用海洋学学报，2023，42（2） ：
Pharmacology and Toxicology, 2001, 15(6): 434 − 440. 210 − 217.
［11］ Yin X Z, Kiriake A, Ohta A, et al. A novel function of Zhang H Y, Lin T, Wu B, et al. Screening, identification
vitellogenin subdomain, vWF type D, as a toxin-binding and dialysis culture of a tetrodotoxin-producing strain[J].
protein in the pufferfish Takifugu pardalis ovary[J]. Journal of Applied Oceanography, 2023, 42(2): 210 −
Toxicon, 2017, 136: 56 − 66. 217.
［12］ Jurcakova D, Ru F, Kollarik M, et al. Voltage-gated so- ［21］ 杨紫涵，蔡水淋，许旻，等. 产河豚毒素微生物的研
dium channels regulating action potential generation in 究进展 [J]. 渔业研究，2024，46（4） ：403 − 412.
itch-, nociceptive-, and low-threshold mechanosensitive Yang Z H, Cai S L, Xu M, et al. Research progress of
cutaneous C-fibers[J]. Molecular Pharmacology, 2018, tetrodotoxin-producing microorganisms[J]. Journal of
94(3): 1047 − 1056. Fisheries Research, 2024, 46(4): 403 − 412.
［13］ 陈素青，任雷鸣. 河豚毒素的药理作用及临床应用 ［22］ Ellington A D, Szostak J W. In vitro selection of RNA
[J]. 中国海洋药物，2001，20（6） ：50 − 55. molecules that bind specific ligands[J]. Nature, 1990,
Chen S Q, Ren L M. Pharmacological and clinical ac- 346(6287): 818 − 822.
tions of tetrodotoxin[J]. Chinese Journal of Marine ［23］ Tuerk C, Gold L. Systematic evolution of ligands by ex-
Drugs, 2001, 20(6): 50 − 55. ponential enrichment: RNA ligands to bacteriophage T4
［14］ Sanford L D, Yang L H, Tang X D, et al. Tetrodotoxin DNA polymerase[J]. Science, 1990, 249(4968): 505 −
inactivation of pontine regions: influence on sleep-wake 510.
states[J]. Brain Research, 2005, 1044(1): 42 − 50. ［24］ Jayasena S D. Aptamers: an emerging class of mo-
［15］ 陈永强. 河豚毒素利多卡因抗心律失常复方制剂的研 lecules that rival antibodies in diagnostics[J]. Clinical
究 [D]. 厦门：国家海洋局第三海洋研究所，2016. Chemistry, 1999, 45(9): 1628 − 1650.
Chen Y Q. Study of tetrodotoxin and lidocaine compound ［25］ Gold L, Ayers D, Bertino J, et al. Aptamer-based multi-
preparation for anti-arrhythmia[D]. Xiamen: Third Insti- plexed proteomic technology for biomarker discovery[J].
tute of Oceanography, State Oceanic Administration, 2016. PLoS One, 2010, 5(12): e15004.
［16］ Matsumura K. Production of tetrodotoxin in puffer fish ［26］ 张洪丽，王婷，张焜和. 核酸适配子的结构特征及其
embryos[J]. Environmental Toxicology and Pharmaco- 对结合性能的影响 [J]. 传感器与微系统，2023，
logy, 1998, 6(4): 217 − 219. 42（8） ：1 − 5，10.
［17］ Magarlamov T Y, Shokur O A, Chernyshev A V. Distri- Zhang H L, Wang T, Zhang K H. Structural characterist-