Page 26 - 《渔业研究》2025年第5期

第 5 期 池雨禹等： 蛋白质翻译后修饰在水产病原菌致病机制中的研究进展 567

lysine acetylation modification of ClpP on the virulence drugs[J]. Frontiers in Cellular and Infection Microbio-
of Vibrio alginolyticus[J]. Molecules, 2024, 29(17): logy, 2022, 12: 977944.
4278. ［50］ Paniz M I, Tina R L, Farzaneh D, et al. Bacterial quor-
［39］ Ouidir T, Cosette P, Jouenne T, et al. Proteomic profil- um sensing: a double-edged sword in cancer develop-

ing of lysine acetylation in Pseudomonas aeruginosa re- ment[J]. Advanced Biology, 2025, 6: e00023.
veals the diversity of acetylated proteins[J]. Proteomics, ［51］ Pratt J T, Ismail A M, Camilli A. PhoB regulates both
2015, 15(13): 2152 − 2157. environmental and virulence gene expression in Vibrio
［40］ Huang H, Lin S, Garcia B A, et al. Quantitative proteom- cholerae[J]. Molecular Microbiology, 2010, 77(6): 1595 −
ic analysis of histone modifications[J]. Chemical Re- 1605.
views, 2015, 115(6): 2376 − 2418. ［52］ Li D, Ramanathan S, Wang G B, et al. Acetylation of
［41］ Povolotsky T L, Levy Barazany H, Shacham Y, et al. lysine 7 of AhyI affects the biological function in
Bacterial epigenetics and its implication for agriculture, Aeromonas hydrophila[J]. Microbial Pathogenesis, 2020,
probiotics development, and biotechnology design[J]. 140: 103952.
Biotechnology Advances, 2024, 75: 108414. ［53］ Sang Y, Ren J, Qin R, et al. Acetylation regulating pro-
［42］ Stojkova P, Spidlova P, Stulik J. Nucleoid-associated tein stability and DNA-binding ability of HilD, thus
protein HU: a lilliputian in gene regulation of bacterial modulating Salmonella typhimurium virulence[J]. The
virulence[J]. Frontiers in Cellular and Infection Micro- Journal of Infectious Diseases, 2017, 216(8): 1018 −
biology, 2019, 9: 159. 1026.
［43］ Barlow V L, Tsai Y H. Acetylation at lysine 86 of Es- ［54］ Xiao X, Li W X, Pan Y F, et al. Holistic analysis of lys-
cherichia coli HUβ modulates the DNA-binding capabil- ine acetylation in aquaculture pathogenic bacteria Vibrio
ity of the protein[J]. Frontiers in Microbiology, 2022, alginolyticus under bile salt stress[J]. Frontiers in Veter-
12: 809030. inary Science, 2023, 10: 1099255.
［44］ Sakatos A, Babunovic G H, Chase M R, et al. Posttrans- ［55］ Liimatta K, Flaherty E, Ro G, et al. A putative acetyla-
lational modification of a histone-like protein regulates tion system in Vibrio cholerae modulates virulence in
phenotypic resistance to isoniazid in mycobacteria[J]. arthropod hosts[J]. Applied and Environmental Microbi-
Science Advances, 2018, 4(5): eaao1478. ology, 2018, 84(21): e01113-18.
［45］ Ghosh S, Padmanabhan B, Anand C, et al. Lysine acet- ［56］ Wang Y Q, Wang G B, Zhang L S, et al. Aeromonas hy-
+
2+
ylation of the Mycobacterium tuberculosis HU protein drophila CobQ is a new type of NAD - and Zn -inde-
modulates its DNA binding and genome organization[J]. pendent protein lysine deacetylase[J]. eLife, 2025, 13:
Molecular Microbiology, 2016, 100(4): 577 − 588. RP97511.
［46］ Carabetta V J. Addressing the possibility of a histone- ［57］ Li S Y, Gong X T, Yin L W, et al. Acetylation of CspC
like code in bacteria[J]. Journal of Proteome Research, controls the Las quorum-sensing system through transla-
2021, 20(1): 27 − 37. tional regulation of rsaL in Pseudomonas aeruginosa[J].
［47］ Grove A, Lim L. High-affinity DNA binding of HU pro- mBio, 2022, 13(3): e0054722.
tein from the hyperthermophile Thermotoga maritima[J]. ［58］ Smedley J G, Jewell E, Roguskie J, et al. Influence of
Journal of Molecular Biology, 2001, 311(3): 491 − 502. pilin glycosylation on Pseudomonas aeruginosa 1244
［48］ Bettridge K, Verma S, Weng X L, et al. Single-molecule pilus function[J]. Infection and Immunity, 2005, 73(12):
tracking reveals that the nucleoid-associated protein HU 7922 − 7931.
plays a dual role in maintaining proper nucleoid volume ［59］ Verma A, Schirm M, Arora S K, et al. Glycosylation of
through differential interactions with chromosomal DNA b-type flagellin of Pseudomonas aeruginosa: structural
[J]. Molecular Microbiology, 2021, 115(1): 12 − 27. and genetic basis[J]. Journal of Bacteriology, 2006,
［49］ Casado J, Lanas Á, González A. Two-component regu- 188(12): 4395 − 4403.
latory systems in Helicobacter pylori and Campylobac- ［60］ Fulton K M, Mendoza-Barberá E, Twine S M, et al. Po-
ter jejuni: attractive targets for novel antibacterial lar glycosylated and lateral non-glycosylated flagella