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678 渔 业 研 究 第 47 卷

赖的方式通过双向调节激活 Na-K-Cl 协同转运蛋 fection[J]. Journal of Aquatic Animal Health, 1994,
–
白 1[Cl -importing Na-(K)-2Cl cotransporters，NKCC1] 6(2): 101 − 109.
并抑制 K-Cl 协同转运蛋白 2（Cl -exporting K-Cl ［ 8 ］ Cooper Ⅱ R K, Shotts E B Jr, Nolan L K. Use of a mini-
–
cotransporters，KCC2） ，从而促进 Cl 积累 [39] ，而 transposon to study chondroitinase activity associated
–
–
Cl 积累可抑制 NLRP3 炎症小体的激活，这与其他 with Edwardsiella ictaluri[J]. Journal of Aquatic Anim-
WNK 基因的功能相反，本研究中 YG 组中 WNK2 al Health, 1996, 8(4): 319 − 324.
的显著表达原因尚不明确，未来需继续进行研究。 ［ 9 ］ Li C, Zhang Y, Wang R J, et al. RNA-seq analysis of
总而言之，杀鱼爱德华氏菌感染后 YG 组和 KX 组 mucosal immune responses reveals signatures of intestin-
肠道和肝脏中 WNK1a、WNK1b、WNK2、WNK3、 al barrier disruption and pathogen entry following Ed-
WNK4a 和 WNK4b 基因的显著表达变化支持斑点叉 wardsiella ictaluri infection in channel catfish, Ictalurus
尾鮰WNK 基因参与 ESC 疾病过程的观点。 punctatus[J]. Fish & Shellfish Immunology, 2012,
32(5): 816 − 827.
［10］ Kalindamar S, Abdelhamed H, Kordon A O, et al.
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