Page 18 - 《运动与健康科学》(英文)2024年第2期

TaggedAPTARAFigure TaggedAPTARAEnd140 M. Rodriguez-Ayllon et al.

Fig. 5. Forest plot of pooled ES and confidence intervals of observational studies exploring the association between physical activity and blood Ab. When the
same study presented more than one effect size, a number was included after the ES. Q: the Q test is typically used to test the homogeneity of effect sizes as well
as the impact of moderators. INNO-BIA: a commercial kit to assess Ab (Innogenetics, Inc., Gent, Belgium). 95%CI = 95% confidence interval; Ab = amyloid
beta; Cross = cross-sectional studies; ES = effect size; ELISA = enzyme-linked immunoassay; Long = longitudinal cohort studies.TaggedAPTARAEnd

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SMD = 0.083, 95%CI: 0.216 to 0.049, I = 79.85%), we did not find evidence of publication bias based on visual
Ab42 (pooled SMD = 0.091, 95%CI: 0.190 to 0.009, observation of the funnel plots and Egger’s tests (Supplemen-
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I = 54.45%), and Ab40 (pooled SMD = 0.046, 95%CI: tary Figs. 35).TaggedAPTARAEnd
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0.163 to 0.071, I = 66.57%). Only a single study reported
the ratio Ab40/42. 58 Therefore, these data were excluded
TaggedAPTARAH14. DiscussionTaggedAPTARAEnd
from the general pool, and we were not able to meta-
TaggedAPTARAPThe main findings of this review suggest that exercise inter-
analyze them separately.TaggedAPTARAEnd
TaggedAPTARAPModeration analysis by population (cognitively normal vs. ventions of 1252 weeks have a medium effect on blood Ab
cognitively impaired) revealed no moderation effect in CSF levels in middle-aged and older adults. Notably, only a few
analysis (omnibus test of moderators = 8.44, p = 0.88) and studies were included in the meta-analysis, and the results
brain (omnibus test of moderators = 6.68, p = 0.20) analysis were not statistically significant. Therefore, caution is needed
(Fig. 6). We did not run moderation analyses by population in in interpreting these findings. In addition, there were not
blood because all participants were cognitively normal. Lastly, enough studies in the literature to meta-analyze the effects of
TaggedAPTARAFigure

Fig. 6. Forest plot of moderation analysis of observational studies by population. All studies included in these analyses used the isoform Ab42 when they assessed
Ab in the CSF. Q: the Q test is typically used to test the homogeneity of effect sizes as well as the impact of moderators. 95%CI = 95% confidence interval;
Ab = amyloid beta; CSF = cerebrospinal fluid.TaggedAPTARAEnd