Page 11 - 《运动与健康科学》(英文)2024年第2期

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Journal of Sport and Health Science 13 (2024) 133144

Review

TaggedAPTARAH1Physical activity and amyloid beta in middle-aged and older adults:

A systematic review and meta-analysisTaggedAPTARAEnd

b
TaggedAPTARAPMar ıa Rodriguez-Ayllon a,y , Patricio Solis-Urra b,c,d,y , Cristina Arroyo-Avila ,

b
f
d
e
Miriam Alvarez-Ortega , Pablo Molina-Garc ıa , Cristina Molina-Hidalgo , Manuel G omez-R ıo ,
Belinda Brown g,h , Kirk I. Erickson b,f,g,h,i , Irene Esteban-Cornejo b,j, *TaggedAPTARAEnd
a
TaggedAPTARAP Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, GD 3015, the Netherlands
b
Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS),
University of Granada, Granada 18071, Spain
c
Faculty of Education and Social Sciences, Universidad Andres Bello, Vi~ na del Mar 2531015, Chile
d
Department of Nuclear Medicine, Virgen de las Nieves University Hospital, Institute of Biosanitary Research of Granada (IBS), Granada 18014, Spain
e
Physical Medicine and Rehabilitation Service, Virgen de las Nieves University Hospital, Institute of Biosanitary Research of Granada (IBS), Granada 18014, Spain
f
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
g Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia
h
School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia
i
Advent Health Research Institute, Neuroscience Institute Orlando, Orlando, FL 32803, USA
j
Physiopathology of Obesity and Nutrition Research Center (CIBERobn), Institute of Health Carlos III (ISCIII), Madrid 28029, Spain
TaggedAPTARAEnd Received 11 October 2022; revised 11 February 2023; accepted 30 June 2023
Available online 7 August 2023
2095-2546/Ó 2024 Published by Elsevier B.V. on behalf of Shanghai University of Sport. This is an open access article under the CC BY-NC-ND license.
(http://creativecommons.org/licenses/by-nc-nd/4.0/)
TaggedAPTARAPAbstract
Background: One of the pathological hallmarks distinguishing Alzheimer’s disease from other dementias is the accumulation of amyloid beta (Ab).
Higher physical activity is associated with decreased dementia risk, and one potential path could be through Ab levels modulation. We aimed to
explore the relationship between physical activity and Ab in middle-aged and older adults.
Methods: A systematic search of PubMed, Web of Science, PsycINFO, Cochrane Central Register of Controlled Trials, and SPORTDiscus was performed
from inception to April 28, 2022. Studies were eligible if they included physical activity and Ab data in adults aged 45 years or older. Multi-level meta-
analyses of intervention and observational studies were performed to examine the role of physical activity in modulating Ab levels.
Results: In total, 37 articles were included (8 randomized controlled trials, 3 non-randomized controlled trials, 4 prospective longitudinal studies,
and 22 cross-sectional studies). The overall effect size of physical activity interventions on changes in blood Ab was medium (pooled standard-
2
ized mean difference = 0.69, 95% confidence interval (95%CI): 1.41 to 0.03; I = 74.6%). However, these results were not statistically signifi-
cant, and there were not enough studies to explore the effects of physical activity on cerebrospinal fluid (CSF) and brain Ab. Data from
observational studies were examined based on measurements of Ab in the brain using positron emission tomography scans, CSF, and blood.
2
Higher physical activity was positively associated with Ab only in the CSF (Estimate r = 0.12; 95%CI: 0.050.18; I = 38.00%).
Conclusion: Physical activity might moderately reduce blood Ab in middle-aged and older adults. However, results were only near statistical
significance and might be interpreted with caution given the methodological limitations observed in some of the included studies. In observa-
tional studies, higher levels of physical activity were positively associated with Ab only in CSF. Therefore, further research is needed to under-
stand the modulating role of physical activity in the brain, CSF, and blood Ab, as well as its implication for cognitive health.
TaggedAPTARAPKeywords: Aging; Cognitive impairment; Dementia; Exercise; PETTaggedAPTARAEnd

TaggedAPTARAH11. IntroductionTaggedAPTARAEnd
TaggedAPTARAPLife expectancy is increasing globally in tandem with the
TaggedAPTARAEndTaggedAPTARAEnd Peer review under responsibility of Shanghai University of Sport. number of people living with dementia and cognitive impairment.
TaggedAPTARAEnd* Corresponding author.
E-mail address: ireneesteban@ugr.es (I. Esteban-Cornejo). In particular, Alzheimer’s disease (AD) is the major cause of
1
y cognitive decline and dementia worldwide. AD is characterized
TaggedAPTARAEnd These two authors contributed equally to this work.
https://doi.org/10.1016/j.jshs.2023.08.001
Cite this article: Rodriguez-Ayllon M, Solis-Urra P, Arroyo- Avila C, et al. Physical activity and amyloid beta in middle-aged and older adults: A systematic
review and meta-analysis. J Sport Health Sci 2024;13:13344.