Page 110 - 《水产学报》2026年第3期

3 期 水 产 学 报 50 卷

上调
up-regulate
AMPKa/ IRA/IRB/IRS1/
SIRT1
增加 PEPCK/AKT1/PBP1
33℃ 持续暴露 8 周 increase /GSK3β 下调
prolonged 去乙酰化 抑制 抑制 down-regulate
exposure to 33℃ deacet ylation inhibit inhibit
for 8 weeks IκBβ/P65/
Iκκβ/IL-8
FAS/LPL/HSL下调
PGC-1a 免疫功能削弱 down-regulate
impaired immune ACC/CPT-
function 1/ATGL/FFAR 上调
下调 加剧 up-regulate
down-regulate aggravate 减少
decrease
DRP1/ 糖脂代谢紊乱
ERRa/TF FIS1 P62/ 线粒体稳态失衡及功能障碍 glucose and lipid
AM7 OPA1/ LC3 mitochondrial homeostasis metabolism
imbalance and dysfunction
MFN1 disorder
下调 下调
down-regulate down-regulate

图 7 CHS 破坏“线粒体动力学-糖脂代谢-能量稳态轴”诱导肝脏糖脂异常沉积
Fig. 7 CHS disrupts the mitochondrial dynamics-glycolipid metabolism-energy homeostasis axis,
inducing abnormal hepatic glycolipid accumulation
Zhang Y J. Effects of high temperature on routine metabolism
（作者声明本文无利益冲突）
and hypoxia tolerance of tilapia[D]. Shanghai: Shanghai Ocean
University, 2022 (in Chinese).
参考文献
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