Page 11 - 《水产学报》2025年第6期

艾庆辉，等 水产学报, 2025, 49(6): 069601

CTP: phosphocholine cytidylyltransferase alpha (CCTα) - advances on its
role and regulation in memebrane lipid biogenesis and lipid metabolism

1,2*
AI Qinghui , ZHAN Rui 1
1. Key Laboratory of Mariculture, Ministry of Education,
Key Laboratory of Aquaculture Nutrition and Feed, Ministry of Agriculture and Rural Affairs,
Ocean University of China, Qingdao 266003, China;
2. Laboratory for Marine Fisheries Science and Food Production Processes,
Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China

Abstract: Phosphatidylcholine (PC) is a major component of membrane phospholipids and plays essential biological roles. The
primary pathway for PC synthesis is the CDP-choline pathway, in which CTP: phosphocholine cytidylyltransferase (CCT)
functions as the rate-limiting enzyme and is a key factor in maintaining PC homeostasis. CCTα, one of the major isoforms of
the CCT family, is widely distributed across mammalian organs and tissues, and plays crucial roles in membrane biogenesis and
lipid metabolism. Recent studies have shown that CCTα is also present in fish and exerts important regulatory functions in fish
lipid metabolism. This review summarizes the functions and regulatory mechanisms of CCTα in both mammals and fish, with a
focus on its roles in membrane biogenesis and lipid metabolism. Additionally, the potential of CCTα as a molecular target for
regulating nutritional metabolic disorders in fish is explored, aiming to provide a theoretical implications for the healthy devel-
opment of aquaculture.
Key words: CTP: choline-phosphate cytidylyltransferase α (CCTα); phosphatidylcholine; membrane lipid biosynthesis; lipid
metabolism
Corresponding author: AI Qinghui. E-mail: qhai@ouc.edu.cn

Funding projects: National Natural Science Foundation of China (31830103, U2106232); China Agriculture Research System
of MOF and MARA (CARS-47-11)

https://www.china-fishery.cn 中国水产学会主办 sponsored by China Society of Fisheries
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