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综上，CCTα 作为脂质代谢中的重要调控因 thesis[J]. Proceedings of the National Academy of Sciences of
子，未来可作为一个潜在靶点，研究其在脂质代 the United States of America, 1990, 87(16): 6029-6033.
谢中的作用，为缓解高脂或高比例植物油替代 [12] Rutherford M S, Rock C O, Jenkins N A, et al. The gene for
鱼油所导致的脂肪异常沉积提供营养学策略。 murine CTP: phosphocholine cytidylyltransferase (Ctpct) is loc-
ated on mouse chromosome 16[J]. Genomics, 1993, 18(3): 698-
参考文献 (References)： 701.
[13] Wang Y L, Sweitzer T D, Weinhold P A, et al. Nuclear localiz-
[ 1 ] Kennedy E P, Weiss S B. The function of cytidine coenzymes
ation of soluble CTP: phosphocholine cytidylyltransferase[J].
in the biosynthesis of phospholipides[J]. Journal of Biological
The Journal of Biological Chemistry, 1993, 268(8): 5899-5904.
Chemistry, 1956, 222(1): 193-214.
[14] Helmink B A, Braker J D, Kent C, et al. Identification of lysine
[ 2 ] Aitchison A J, Arsenault D J, Ridgway N D. Nuclear-localized
122 and arginine 196 as important functional residues of rat
CTP: phosphocholine cytidylyltransferase α regulates phos-
CTP: phosphocholine cytidylyltransferase alpha[J]. Biochem-
phatidylcholine synthesis required for lipid droplet
istry, 2003, 42(17): 5043-5051.
biogenesis[J]. Molecular Biology of the Cell, 2015, 26(16):
[15] Johnson J E, Cornell R B. Amphitropic proteins: regulation by
2927-2938.
[ 3 ] Morita S Y, Ikeda Y. Regulation of membrane phospholipid reversible membrane interactions (review)[J]. Molecular Mem-
brane Biology, 1999, 16(3): 217-235.
biosynthesis in mammalian cells[J]. Biochemical Pharmaco-
[16] Arnold R S, Cornell R B. Lipid regulation of CTP:phos-
logy, 2022, 206: 115296.
phocholine cytidylyltransferase: electrostatic, hydrophobic, and
[ 4 ] Cornell R B, Northwood I C. Regulation of CTP: phos-
synergistic interactions of anionic phospholipids and diacylgly-
phocholine cytidylyltransferase by amphitropism and relocaliz-
ation[J]. Trends in Biochemical Sciences, 2000, 25(9): 441-447. cerol[J]. Biochemistry, 1996, 35(30): 9917-9924.
[ 5 ] Cornell R B, Ridgway N D. CTP: phosphocholine cytidylyl- [17] Davies S M A, Epand R M, Kraayenhof R, et al. Regulation of
transferase: function, regulation, and structure of an CTP: phosphocholine cytidylyltransferase activity by the phys-
ical properties of lipid membranes: an important role for stored
amphitropic enzyme required for membrane biogenesis[J]. Pro-
gress in Lipid Research, 2015, 59: 147-171. curvature strain energy[J]. Biochemistry, 2001, 40(35): 10522-
[ 6 ] Haider A, Wei Y C, Lim K, et al. PCYT1A regulates phos- 10531.
phatidylcholine homeostasis from the inner nuclear membrane [18] Johnson J E, Xie M T, Singh L M R, et al. Both acidic and
in response to membrane stored curvature elastic stress[J]. basic amino acids in an amphitropic enzyme, CTP: phos-
Developmental Cell, 2018, 45(4): 481-495. phocholine cytidylyltransferase, dictate its selectivity for
[ 7 ] Lykidis A, Baburina I, Jackowski S. Distribution of CTP: phos- anionic membranes[J]. Journal of Biological Chemistry, 2003,
phocholine cytidylyltransferase (CCT) isoforms: identification 278(1): 514-522.
of a new CCTβ splice variant[J]. Journal of Biological Chem- [19] Chong S S Y, Taneva S G, Lee J M C, et al. The curvature
istry, 1999, 274(38): 26992-27001. sensitivity of a membrane-binding amphipathic helix can be
[ 8 ] Taneva S, Dennis M K, Ding Z W, et al. Contribution of each modulated by the charge on a flanking region[J]. Biochemistry,
membrane binding domain of the CTP: phosphocholine 2014, 53(3): 450-461.
cytidylyltransferase-α dimer to its activation, membrane bind- [20] Watkins J D, Kent C. Regulation of CTP: phosphocholine
ing, and membrane cross-bridging[J]. Journal of Biological cytidylyltransferase activity and subcellular location by phos-
Chemistry, 2008, 283(42): 28137-28148. phorylation in Chinese hamster ovary cells. The effect of phos-
[ 9 ] Dingwall C, Laskey R A. Nuclear targeting sequences-a con- pholipase c treatment[J]. Journal of Biological Chemistry, 1991,
sensus?[J]. Trends in Biochemical Sciences, 1991, 16: 478-481, 266(31): 21113-21117.
[10] Wang Y L, Macdonald J I S, Kent C. Identification of the nuc- [21] Wang Y L, MacDonald J I S, Kent C. Regulation of CTP: phos-
lear localization signal of rat liver CTP: phosphocholine phocholine cytidylyltransferase in hela cells. Effect of oleate on
cytidylyltransferase[J]. Journal of Biological Chemistry, 1995, phosphorylation and intracellular localization[J]. Journal of
270(1): 354-360. Biological Chemistry, 1993, 268(8): 5512-5518.
[11] Kalmar G B, Kay R J, Lachance A, et al. Cloning and expres- [22] Houweling M, Jamil H, Hatch G M, et al. Dephosphorylation of
sion of rat liver CTP: phosphocholine cytidylyltransferase: an CTP-phosphocholine cytidylyltransferase is not required for
amphipathic protein that controls phosphatidylcholine syn- binding to membranes[J]. Journal of Biological Chemistry,

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