Page 59 - 《中国医疗器械杂志》2025年第6期

Chinese Journal of Medical Instrumentation 2025年 第49卷 第6期

综 合 评 述

印技术构建负载Kartogenin纳米颗粒的重组胶原蛋 hydroxylation for functional recombinant collagen in
白/壳聚糖甲基丙烯酸酯/纳米黏土复合水凝胶支 Escherichia coli[J]. Int J Biol Macromol, 2024, 282(Pt 5):
137400.
架，支架兼具抗菌性、生物相容性和药物缓释功
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能，可有效诱导干细胞软骨分化并促进体内软骨再 characterization of hydroxylated recombinant collagen by
生 。基于重组胶原的3D打印技术正推动复杂组 incorporating proline and hydroxyproline in proline-
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织再生革新，突破传统移植材料的功能局限，以上 deficient Escherichia coli[J]. Bioengineering, 2024,
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研究验证了从单一组织修复到管腔器官再生的跨尺
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度应用潜力，未来须融合多材料打印与动态信号编 type Ⅲ collagen inhibits ovarian cancer and induces
程，开发适配异质组织界面的智能胶原基植入体。 protective anti-tumor immunity by regulating autophagy
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凭借可编程分子结构和优异生物相容性特性，通过 2024, 72(24): 13622-13633.
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子设计策略与精准发酵等制备工艺创新，可显著提
for wound regeneration: mediated by metal coordination
升力学性能与生物活性，在再生医学、组织工程、 crosslinking and reinforced by electro-oxidized tea
药物递送及创面修复等医疗器械领域实现突破性应 polyphenols[J]. Biofabrication, 2024, 17(1): 015027.
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物学推动产业化升级。未来，希望可突破重组胶原 3279.
蛋白规模化生产、长期安全性等瓶颈，通过多学科 [15] BOCHOVE V B, WARMINK L, ANKONE M, et al.
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